|
Autoantibody measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
Autoantibody measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
Blood Protein Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
We assessed the association between three single nucleotide polymorphisms (SNPs) of the MHC2TA (-168G/A; rs3087456, and +16G/C; rs4774) and FCRL3 (-169T/C; rs7528684) genes and rheumatoid arthritis in Mexican population through a genotyping method using allelic discrimination assays with TaqMan probes.
|
26350270 |
2016 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
In terms of stratified analyses by ethnicity and disease phenotypes, there were significant associations of rs7528684 polymorphism both with ADs in Asians and Europeans, and with rheumatoid arthritis, Graves' disease, type-1 diabetes, and other ADs under different genetic models.
|
24117236 |
2013 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
We found some evidence for an association of either rs7528684/fcrl3_3 or rs3792876/slc2F2 with RA; however, because the magnitudes of effects were apparently much weaker than those reported in the initial positive reports, and there were substantial levels of inter-study OR heterogeneity, we concluded that additional studies are needed to fully understand the present results.
|
18087673 |
2008 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
A promoter polymorphism of FCRL3 (rs7528684) is associated with an increased risk of developing RA in Dutch Caucasians, suggesting that this association is relevant for RA in both Japanese and Caucasian populations.
|
17179172 |
2007 |
|
Rheumatoid Arthritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Four single nucleotide polymorphism (SNP) markers (FCRL3-169*C/T (fclr3_3, rs7528684), fclr3_4 (rs11264799), fclr3_5 (rs945635), fclr3_6 (rs3761959)) all previously associated with RA in a Japanese population were genotyped in 761 RA samples and 484 controls.
|
16859508 |
2006 |
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Fcrl3 -169T>C (rs7528684) polymorphism has been shown to be a risk factor of various autoimmune diseases, including systemic lupus erythematosus (SLE); however, these results are inconsistent between distinct ethnicities.
|
24593204 |
2014 |
|
Autoimmune Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Fcrl3 -169T>C (rs7528684) polymorphism has been shown to be a risk factor of various autoimmune diseases, including systemic lupus erythematosus (SLE); however, these results are inconsistent between distinct ethnicities.
|
24593204 |
2014 |
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our aim was to determine whether the Fc receptor-like 3 (FCRL3) -169 C/T (rs7528684) polymorphism confers susceptibility to systemic lupus erythematosus (SLE).
|
23512175 |
2013 |
|
Endometriosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Recently, the FCRL3 -169T>C (rs7528684) single-nucleotide polymorphism (SNP) has been demonstrated to be a risk factor of endometriosis related infertility.
|
23553198 |
2013 |
|
Autoimmune Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
In terms of stratified analyses by ethnicity and disease phenotypes, there were significant associations of rs7528684 polymorphism both with ADs in Asians and Europeans, and with rheumatoid arthritis, Graves' disease, type-1 diabetes, and other ADs under different genetic models.
|
24117236 |
2013 |
|
Graves Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Above data indicated that FCRL3 gene and its proxy SNP rs7528684 may be involved in the pathogenesis of GD by excessive inhibiting B cell receptor signaling and the impairment of suppressing function of Tregs.
|
23505439 |
2013 |
|
Endometriosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
To consider a possible cumulative effect of two genetic polymorphisms (FOXP3 C-2383T/rs3761549 and FCRL3 C-169T/rs7528684) that were previously shown to be associated with endometriosis.
|
22341374 |
2012 |
|
Graves Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
These preliminary results demonstrate that the immune-regulatory gene CTLA-4 and the thyroid-specific gene Tg contribute to the risk of Graves' disease with additive effects, while PTPN22 rs3789604 and FCRL3 rs7528684 polymorphisms are protective against the disease.
|
19438904 |
2010 |
|
Allergic rhinitis (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequencies of the rs7528684 A allele (Pc = 1.80 × 10<sup>-3</sup>) and the rs10489678 G allele (Pc = 0.04) within FCRL3 were higher in asthma with comorbid AR than in controls.
|
30771554 |
2019 |
|
Behcet Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analysis of the alleles revealed a significantly lower frequency of the A allele at the -169 site (rs7528684) in BD patients compared with that in controls (<i>P</i>=0.000, 66.4% versus 82%, χ<sup>2</sup>= 30.23).
|
31341856 |
2019 |
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequencies of the rs7528684 A allele (Pc = 1.80 × 10<sup>-3</sup>) and the rs10489678 G allele (Pc = 0.04) within FCRL3 were higher in asthma with comorbid AR than in controls.
|
30771554 |
2019 |
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
This analysis results performed that four SNPs, rs7528684 (FCRL3_3), rs945635 (FCRL3_5), rs3761959 (FCRL3_6), and rs2282284 (FCRL3_8), were significantly associated with the risk of MS. Further haplotype analysis showed two haplotypes of FCRL3_3, 5, 6, 8, CCAG and CGAG, presented the significant associations with the susceptibility to MS. Four SNPs in FCRL3 gene could possibly associate with the susceptibility of MS in a Chinese Han population.
|
25862376 |
2016 |
|
Sudden sensorineural hearing loss
|
|
0.010 |
GeneticVariation
|
BEFREE |
Five single-nucleotide polymorphisms (SNPs) in FCRL3-rs945635, rs3761959, rs7522061, rs10489678, and rs7528684-were genotyped in 630 patients with SSNHL and 600 healthy controls by using a PCR-restriction fragment length polymorphism assay.
|
26051414 |
2015 |