|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.090 |
GeneticVariation
|
BEFREE |
At the 12q24 locus, the Proteasome-Modulator 9 (PSMD9) single nucleotide polymorphisms (SNPs) rs74421874 [intervening sequence (IVS) 3+nt460-G>A], rs3825172 (IVS3+nt437-C>T) and rs14259 (E197G-A>G) are linked to: T2D, depression, anxiety, maturity-onset-diabetes-of the young 3/MODY3, obesity, waist circumference, hypertension, hypercholesterolemia, T2D-macrovascular disease, T2D-microvascular disease, T2D-neuropathy, T2D-carpal-tunnel syndrome, T2D-nephropathy, T2D-retinopathy and non-diabetic retinopathy.
|
26166263 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.090 |
GeneticVariation
|
BEFREE |
The 200 Italians families were tested for the PSMD9 T2D risk SNPs rs74421874 (IVS3 + nt460 G>A), rs3825172 (IVS3 +nt437 T>C) and for the T2D risk and anti-depressant response SNP rs1043307/rs2514259 (E197G A>G) for evidence of linkage with generalized anxiety disorder.
|
24648162 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.090 |
GeneticVariation
|
BEFREE |
In summary, the PSMD9 IVS3 + nt460, IVS3 + nt437, E197G SNPs are linked via the recessive model to microvascular pathology of T2D in Italians.
|
22015693 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.090 |
GeneticVariation
|
BEFREE |
We report the linkage study of the PSMD9 SNPs [intervening sequence IVS3+nt460A/G, IVS3+nt437C/T and E197G] in Italian families with T2D neuropathy.
|
21813292 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.090 |
GeneticVariation
|
BEFREE |
We tested the PSMD9 T2D risk SNPs IVS3+nt460A>G, IVS3+nt437T>C and E197G for linkage to T2D-diabetic nephropathy in 200 Italians T2D families and show linkage to diabetic nephropathy.
|
21439668 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.090 |
GeneticVariation
|
BEFREE |
We tested in the 200 Italians families for the presence of the linkage of the PSMD9 T2D risk single nucleotide polymorphisms (SNPs) IVS3+nt460 A > G, IVS3+nt437 T > C and E197G A > G with elevated blood pressure/hypertension.
|
21871126 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.090 |
GeneticVariation
|
BEFREE |
In the present study, we aimed at determining whether the PSMD9 T2D risk single nucleotide polymorphisms (SNPs) IVS3 + nt460 A > G, IVS3 + nt437 T > C and E197G A > G are linked to hypercholesterolemia in 200 T2D Italian families.
|
21554682 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.090 |
GeneticVariation
|
BEFREE |
In summary, the PSMD9 IVS3+nt460A/G, +nt437C/T and exon E197G A/G SNPs are linked to CAD, stroke/TIA and macrovascular pathology of T2D in Italians.
|
21496327 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.090 |
GeneticVariation
|
BEFREE |
The aim of this study was to identify linkage of the proteasome modulator 9 (PSMD9) T2D risk variants IVS3+nt460, IVS3+nt437, E197G to diabetic retinopathy and retinopathy including also atherosclerotic or hypertensive retinopathy in Italian T2D families.
|
21728808 |
2011 |
|
Mental Depression
|
|
0.020 |
GeneticVariation
|
BEFREE |
PSMD9 SNP rs74421874 [intervening sequence (IVS) 3 + nt460 G>A], rs3825172 (IVS3 + nt437 C>T) and rs1043307/rs2514259 (E197G A>G) are all linked to type 2 diabetes (T2D), maturity-onset-diabetes-of the young 3 (MODY3), obesity and waist circumference, hypertension, hypercholesterolemia, T2D-macrovascular and T2D-microvascular disease, T2D-neuropathy, T2D-carpal tunnel syndrome, T2D-nephropathy, T2D-retinopathy, non-diabetic retinopathy and depression.
|
24648162 |
2014 |
|
Diabetic Retinopathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
PSMD9 SNP rs74421874 [intervening sequence (IVS) 3 + nt460 G>A], rs3825172 (IVS3 + nt437 C>T) and rs1043307/rs2514259 (E197G A>G) are all linked to type 2 diabetes (T2D), maturity-onset-diabetes-of the young 3 (MODY3), obesity and waist circumference, hypertension, hypercholesterolemia, T2D-macrovascular and T2D-microvascular disease, T2D-neuropathy, T2D-carpal tunnel syndrome, T2D-nephropathy, T2D-retinopathy, non-diabetic retinopathy and depression.
|
24648162 |
2014 |
|
Depressed mood
|
|
0.020 |
GeneticVariation
|
BEFREE |
PSMD9 SNP rs74421874 [intervening sequence (IVS) 3 + nt460 G>A], rs3825172 (IVS3 + nt437 C>T) and rs1043307/rs2514259 (E197G A>G) are all linked to type 2 diabetes (T2D), maturity-onset-diabetes-of the young 3 (MODY3), obesity and waist circumference, hypertension, hypercholesterolemia, T2D-macrovascular and T2D-microvascular disease, T2D-neuropathy, T2D-carpal tunnel syndrome, T2D-nephropathy, T2D-retinopathy, non-diabetic retinopathy and depression.
|
24648162 |
2014 |
|
Depressive disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
PSMD9 SNP rs74421874 [intervening sequence (IVS) 3 + nt460 G>A], rs3825172 (IVS3 + nt437 C>T) and rs1043307/rs2514259 (E197G A>G) are all linked to type 2 diabetes (T2D), maturity-onset-diabetes-of the young 3 (MODY3), obesity and waist circumference, hypertension, hypercholesterolemia, T2D-macrovascular and T2D-microvascular disease, T2D-neuropathy, T2D-carpal tunnel syndrome, T2D-nephropathy, T2D-retinopathy, non-diabetic retinopathy and depression.
|
24648162 |
2014 |
|
Mental Depression
|
|
0.020 |
GeneticVariation
|
BEFREE |
We tested in the 200 Italians families for evidence of linkage of the PSMD9 single nucleotide polymorphisms (SNPs) IVS3+nt460 A > G, IVS3+nt437 T > C and E197G A > G with the depression phenotype.
|
22934761 |
2012 |
|
Depressive disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
We tested in the 200 Italians families for evidence of linkage of the PSMD9 single nucleotide polymorphisms (SNPs) IVS3+nt460 A > G, IVS3+nt437 T > C and E197G A > G with the depression phenotype.
|
22934761 |
2012 |
|
Depressed mood
|
|
0.020 |
GeneticVariation
|
BEFREE |
We tested in the 200 Italians families for evidence of linkage of the PSMD9 single nucleotide polymorphisms (SNPs) IVS3+nt460 A > G, IVS3+nt437 T > C and E197G A > G with the depression phenotype.
|
22934761 |
2012 |
|
Diabetic Retinopathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
In summary, the PSMD9 IVS3+nt460, IVS3+nt437, E197G SNPs are linked to diabetic retinopathy and non-diabetic retinopathy in Italians.
|
21728808 |
2011 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
PSMD9 SNP rs1043307/rs14259 (E197G-A>G) plays a role in anti-depressant therapy response, depression and schizophrenia.
|
26166263 |
2015 |
|
Sleeplessness
|
|
0.010 |
GeneticVariation
|
BEFREE |
PSMD9 rs74421874 (IVS3+nt460-G>A), rs3825172 (IVS3+nt437-C>T) and rs1043307/rs14259 (E197G-A>G) SNPs are linked to insomnia in our Italian families.
|
26166263 |
2015 |
|
Generalized Anxiety Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
The 200 Italians families were tested for the PSMD9 T2D risk SNPs rs74421874 (IVS3 + nt460 G>A), rs3825172 (IVS3 +nt437 T>C) and for the T2D risk and anti-depressant response SNP rs1043307/rs2514259 (E197G A>G) for evidence of linkage with generalized anxiety disorder.
|
24648162 |
2014 |
|
Neuropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
We report the linkage study of the PSMD9 SNPs [intervening sequence IVS3+nt460A/G, IVS3+nt437C/T and E197G] in Italian families with T2D neuropathy.
|
21813292 |
2012 |
|
Vascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We then screened 200 T2D siblings/families for PSMD9 +nt460A/G, +nt437C/T and exon E197G A/G single nucleotide polymorphisms (SNPs) and performed a non-parametric linkage study to test for linkage for coronary artery disease, stroke/TIA, macro-vasculopathy and macrovascular pathology of T2D.
|
21496327 |
2011 |
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested the PSMD9 T2D risk SNPs IVS3+nt460A>G, IVS3+nt437T>C and E197G for linkage to T2D-diabetic nephropathy in 200 Italians T2D families and show linkage to diabetic nephropathy.
|
21439668 |
2011 |
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We then screened 200 T2D siblings/families for PSMD9 +nt460A/G, +nt437C/T and exon E197G A/G single nucleotide polymorphisms (SNPs) and performed a non-parametric linkage study to test for linkage for coronary artery disease, stroke/TIA, macro-vasculopathy and macrovascular pathology of T2D.
|
21496327 |
2011 |
|
Hypercholesterolemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we aimed at determining whether the PSMD9 T2D risk single nucleotide polymorphisms (SNPs) IVS3 + nt460 A > G, IVS3 + nt437 T > C and E197G A > G are linked to hypercholesterolemia in 200 T2D Italian families.
|
21554682 |
2011 |