rs780094, GCKR

N. diseases: 44
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.860 GeneticVariation BEFREE Although the influence of a common variant in the glucokinase regulatory gene (GCKR rs780094) in type 2 diabetes mellitus has been well documented, less data however, is available of its role in gestational diabetes mellitus (GDM). 29410004 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.860 GeneticVariation GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.860 GeneticVariation BEFREE Although studies have suggested that rs780094, a common variant in the glucokinase regulatory (GCKR) gene to be associated with type 2 diabetes, obesity, and their related traits, the genetic basis of the association between GCKR rs780094 and nonalcoholic fatty liver disease (NAFLD) is still being examined. 25167786 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.860 GeneticVariation BEFREE Our meta-analyses demonstrated that GCKR rs780094 variant confers high cross-ethnicity risk for the development of T2DM, while significant associations between GCK, MTNR1B and G6PC2 variants and T2DM risk are limited to Caucasians. 23840762 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.860 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. 22325160 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.860 GeneticVariation GWASCAT Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.860 GeneticVariation BEFREE Recently, the association of the natural variants rs1260326 and rs780094 of the glucokinase regulatory protein (GCKR) gene with increased fasting triglycerides and decreased fasting plasma glucose in diabetic adults was reported; the minor alleles were also found to reduce the risk of type 2 diabetes. 21511510 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.860 GeneticVariation BEFREE Consistent with observations in white Europeans, the GCKR rs780094 polymorphism contributes to the risk of type 2 diabetes and dyslipidaemia in Han Chinese individuals. 19241058 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.860 GeneticVariation BEFREE The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. 18008060 2008
Diabetes Mellitus, Non-Insulin-Dependent
0.860 GeneticVariation GWASDB Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. 17463246 2007
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.810 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.810 GeneticVariation GWASCAT Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527 2012
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.810 GeneticVariation GWASDB Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527 2012
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.810 GeneticVariation BEFREE Our results support that rs780094 and rs1260326 functional variants of the GCKR gene are inversely associated with serum triglycerides and fasting plasma glucose levels, as it was already reported for diabetic and metabolic syndrome patients in some other populations. 21114848 2011
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.810 GeneticVariation GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282 2011
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.810 GeneticVariation BEFREE Our findings indicate rs780094 has independent associations with multiple metabolic traits as well as incident diabetes, but not incident CHD or stroke. 20661421 2010
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASCAT Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. 28334899 2017
Finding of body mass index
CUI: C0578022
Disease: Finding of body mass index
0.800 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
Glucose measurement
CUI: C0337438
Disease: Glucose measurement
0.800 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
Serum total cholesterol measurement
CUI: C1445957
Disease: Serum total cholesterol measurement
0.800 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
Uric acid measurement (procedure)
CUI: C0202239
Disease: Uric acid measurement (procedure)
0.800 GeneticVariation GWASCAT Modulation of genetic associations with serum urate levels by body-mass-index in humans. 25811787 2016
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.800 GeneticVariation GWASCAT Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2016
Body mass index
CUI: C1305855
Disease: Body mass index
0.800 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
Fasting blood glucose measurement
CUI: C0428568
Disease: Fasting blood glucose measurement
0.800 GeneticVariation GWASCAT Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. 25187374 2015