<b>Methods:</b> We conducted a case-control study in genotyping of five polymorphic loci, including <i>RAN</i> rs14035, <i>XPO5</i> rs11077, <i>DICER1</i> rs13078, <i>DICER1</i> rs3742330, and <i>TARBP2</i> rs784567, in miRNA processing genes to explore the risk factors for T2DM and diabetic vascular complications.
<b>Methods:</b> We conducted a case-control study in genotyping of five polymorphic loci, including <i>RAN</i> rs14035, <i>XPO5</i> rs11077, <i>DICER1</i> rs13078, <i>DICER1</i> rs3742330, and <i>TARBP2</i> rs784567, in miRNA processing genes to explore the risk factors for T2DM and diabetic vascular complications.
Five single nucleotide polymorphisms (SNPs), including Ran-GTP (<i>RAN</i>) rs14035, exportin-5 (<i>XPO5</i>) rs11077, <i>DICER1</i> rs3742330, <i>DICER1</i> rs13078, and <i>TARBP2</i> rs784567, were genotyped in a case-control study to estimate risk factors of cervical precancerous lesions.
We observed a significant association between 2 candidate genes and AD, TARBP2 rs784567 genotype and AD (χ=6.292, P=0.043), and a trend for RNASEN rs10719 genotype (χ=4.528, P=0.104) and allele (P=0.035).
We found nine statistically significant associations with CLL risk after FDR correction, seven in miRNA processing genes (rs3805500 and rs6877842 in DROSHA, rs1057035 in DICER1, rs17676986 in SND1, rs9611280 in TNRC6B, rs784567 in TRBP and rs11866002 in CNOT1) and two in pre-miRNAs (rs11614913 in miR196a2 and rs2114358 in miR1206).