|
Malaria
|
|
0.050 |
GeneticVariation
|
BEFREE |
MyD88-adaptor-like/TIR domain containing adaptor protein polymorphism for single nucleotide polymorphism rs8177374 is related with the susceptibility of malaria.
|
28482182 |
2017 |
|
Malaria
|
|
0.050 |
GeneticVariation
|
BEFREE |
TIRAP S180L polymorphism was typed in 347 cases of severe malaria (SM), 232 uncomplicated malaria and 150 healthy controls.
|
27166096 |
2016 |
|
Malaria
|
|
0.050 |
GeneticVariation
|
BEFREE |
In children with malaria and in uninfected controls enrolled during the study period in the same hospital, blood samples were obtained on filter paper and TLR4 Asp299Gly rs4986790, TLR9 G1174A rs352139, T-1486 C rs187084 TLR9 T-1237 C rs5743836, TIRAP Ser180Leu rs8177374 and the FCGR2A His131Arg rs1801274 polymorphisms were studied using an ABI PRISM 7900 HT Fast Real-time instrument.
|
22691414 |
2012 |
|
Malaria
|
|
0.050 |
GeneticVariation
|
BEFREE |
The comparison of the tirap S180L genotypes between patients with mild malaria and those healthy individuals showed that the frequency of heterozygosity was significantly higher in infected than non-infected individuals (33.8 vs. 25.6; OR, 1.479; 95% CI, 1.051-2.081; P = 0.024).
|
21457584 |
2011 |
|
Malaria
|
|
0.050 |
GeneticVariation
|
BEFREE |
Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy.
|
19602285 |
2009 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The S180L polymorphism, and its murine equivalent S200L, reduced the affinity of Mal for the IFNGR, thereby compromising IFNGR signaling in macrophages and impairing responses to TB.
|
26885859 |
2016 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
However, two other SNPs, C539T and C558T, reported to be associated with tuberculosis in other populations, were found not to be associated with tuberculosis in this Chinese population.
|
21218381 |
2011 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
A mutation (S180L) in the TLR downstream signal transducer TIRAP has recently been reported to be common in Europeans and Africans and to roughly half the risks of heterogeneous infectious diseases including malaria, tuberculosis, bacteremia, and invasive pneumococal disease in heterozygous mutation carriers.
|
19602285 |
2009 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
These results support the influence of TIRAP (MAL) S180L polymorphism on TB and indicate that TB and SLE might share a common immunogenetic pathway in the innate immune response.
|
18417424 |
2008 |
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our finding indicates that TIRAP rs8177374 polymorphism is associated with PTB in a sample of Iranian population.
|
25066393 |
2014 |
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation
|
BEFREE |
Heterozygosity at the polymorphic sites MyD88 rs6853 (alleles: A, G) or TIRAP rs8177374 (S180L) (alleles: C, T) is associated with resistance to pulmonary tuberculosis (P: 7.8 × 10(-8) and 2 × 10(-6), respectively).
|
24067789 |
2013 |
|
Tuberculosis, Pulmonary
|
|
0.030 |
GeneticVariation
|
BEFREE |
The frequency of T allele of TIRAP 975C/T (Ser180Leu) polymorphism was significantly increased among PTB patients as compared to HCs [p = 0.026; Odds ratio (OR) 1.49, 95% Confidence interval (CI) 1.049-2.22].
|
20797905 |
2010 |
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association of TLR4 (D299G, T399I), TLR9 -1486T>C, TIRAP S180L and TNF-α promoter (-1031, -863, -857) polymorphisms with risk for systemic lupus erythematosus among South Indians.
|
25182168 |
2015 |
|
Behcet Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
TIRAP S180L gene polymorphism, which was previously shown to be associated with BD in a Caucasian population, has been replicated in either Turkish or Italian population in our study.
|
24064014 |
2013 |
|
Behcet Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
TIRAP Ser180Leu polymorphism is associated with Behcet's disease.
|
21705416 |
2011 |
|
Rheumatoid Arthritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the influence of the functional TIRAP (MAL) S180L polymorphism on tuberculosis (TB) and four autoimmune diseases namely: rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1D).
|
18417424 |
2008 |
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
These results support the influence of TIRAP (MAL) S180L polymorphism on TB and indicate that TB and SLE might share a common immunogenetic pathway in the innate immune response.
|
18417424 |
2008 |
|
Rheumatoid Arthritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Mal S180L and TLR4 G299D polymorphisms do not contribute to RA susceptibility or severity either individually or in combination.
|
18180278 |
2008 |
|
Lower respiratory tract infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
In that respect, carriage of the TIRAP S180L heterozygous trait increases the likelihood to protect against pneumococcal LRTI, whereas children carrying the mutant homozygous TIRAP 180L polymorphism might be more likely susceptible to recurrent pneumococcal LRTI.
|
30131804 |
2018 |
|
Malaria, Falciparum
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we investigated the association of TIRAP (S180L) polymorphism with susceptibility/resistance to severe P. falciparum malaria in a cohort of adult patients from India.
|
27166096 |
2016 |
|
Complicated malaria
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results of the present study demonstrate that TIRAP S180L heterozygous mutation may protect patients against severe malaria and mortality.
|
27166096 |
2016 |
|
Dengue Fever
|
|
0.010 |
GeneticVariation
|
BEFREE |
Results revealed significantly lower frequency of TLR3 rs3775291 T allele [DHF vs. DF P = 0.015 odds ratio (OR) with 95% confidence interval (CI) 0.390 (0.160–0.880); DHF vs. HC P = 0.018 OR with 95% CI 0.410 (0.170–0.900)] and ‘T’ allele carriers [DHF vs. DF P = 0.008 OR with 95% CI 0.288 (0.115–0.722); DHF vs. HC P = 0.040 OR with 95% CI 0.393 (0.162–0.956)] and higher frequency of TIRAP rs8177374 ‘C/T’ genotype [DHF vs. HC P = 0.020 OR with 95% CI 2.643 (1.167–5.986)] in DHF.
|
25446400 |
2015 |
|
Severe Dengue
|
|
0.010 |
GeneticVariation
|
BEFREE |
Results revealed significantly lower frequency of TLR3 rs3775291 T allele [DHF vs. DF P = 0.015 odds ratio (OR) with 95% confidence interval (CI) 0.390 (0.160–0.880); DHF vs. HC P = 0.018 OR with 95% CI 0.410 (0.170–0.900)] and ‘T’ allele carriers [DHF vs. DF P = 0.008 OR with 95% CI 0.288 (0.115–0.722); DHF vs. HC P = 0.040 OR with 95% CI 0.393 (0.162–0.956)] and higher frequency of TIRAP rs8177374 ‘C/T’ genotype [DHF vs. HC P = 0.020 OR with 95% CI 2.643 (1.167–5.986)] in DHF.
|
25446400 |
2015 |
|
Endometritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, rs5743618, rs4833095, and rs8177374 increased endometritis and/or UGTI, albeit not significantly.
|
23255565 |
2013 |
|
HIV-1 infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of Mal/TIRAP S180L variant polymorphism with decreased infection risk in patients with advanced HIV-1 infection.
|
22683004 |
2012 |