rs894278, SNCA

N. diseases: 4
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.720 GeneticVariation BEFREE Our findings show that rs894278 and PD status interactively affect the brain activity of PD patients and HCs, and changes in the brain connectomes may play a key role in the pathogenesis of P</span>D. 30778284 2019
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.720 GeneticVariation BEFREE The SNP rs894278 confers risk via a dominant model and an additive model, whereas the minor allele G of rs11931074 reduces the risk of PD progression. 23853107 2013
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.720 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815 2012
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.720 GeneticVariation GWASDB Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. 21738487 2011
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.720 GeneticVariation GWASDB Genome-wide association study reveals genetic risk underlying Parkinson's disease. 19915575 2009
PARKINSON DISEASE, LATE-ONSET
CUI: C3160718
Disease: PARKINSON DISEASE, LATE-ONSET
0.010 GeneticVariation BEFREE <b>Conclusions:</b> Hyposmia was associated with RBD in PD patients with the minor G allele of rs894278, which represent one specific subtype of PD. 28979204 2017
REM Sleep Behavior Disorder
CUI: C0751772
Disease: REM Sleep Behavior Disorder
0.010 GeneticVariation BEFREE However, we found that in the group of minor G allele of rs894278, patients with lower score of SS-16 had a 4.76-fold risk of suffering from RBD in patients (95% CI: 1.39-16.67; <i>p</i> = 0.013). 28979204 2017
Sense of smell impaired
CUI: C2364082
Disease: Sense of smell impaired
0.010 GeneticVariation BEFREE <b>Conclusions:</b> Hyposmia was associated with RBD in PD patients with the minor G allele of rs894278, which represent one specific subtype of PD. 28979204 2017