This study was designed to unveil the association of GPR174 rs3827440, PTPN22 rs3789604, and RNASET2 rs9355610 with the onset of liver damage (LD) among the Graves' disease (GD) patients.
Association analysis revealed both rs6832151 located in 4p14 (odds ratio (OR) = 1.27, P <sub>Allelic</sub> = 1.48 × 10<sup>-9</sup>) and rs9355610 located in 6q27 (OR = 1.10, P <sub>Allelic</sub> = 1.04 × 10<sup>-2</sup>) was associated with GD susceptibility.
The C allele of rs3789604 (PTPN22) was a significant risk factor for LD-associated hyperthyroidism in GD patients, whereas C allele of GPR174 rs3827440 and G allele of RNASET2 rs9355610 appeared to be a protective factor for this disease.
Although no significant differences in clinical or biochemical characteristics between patients with PBC and PBC-AITD were seen (all P>0.05), liver function tests and metabolic traits in PBC patients were significantly (all P<0.05) affected by the CTLA4 (rs3087243), MMEL1 (rs2843403), PTPN22 (rs2476601) and RNASET2 (rs9355610) variants.