|
Thyroid carcinoma
|
|
0.850 |
GeneticVariation
|
BEFREE |
Association of rs944289, which was previously known to confer risk for thyroid cancer, with FA, and the correlation between PTCSC3 and NRG1 expression demonstrates that predisposing genetic factors are partly common for benign and malignant thyroid tumors, and imply broader roles of the pathways they underlie in thyroid tumorigenesis, not limited to carcinogenesis.
|
25562676 |
2015 |
|
Thyroid carcinoma
|
|
0.850 |
GeneticVariation
|
BEFREE |
Overall, meta-analysis of rs944289</span> showed 1.11-fold increased risk of thyroid cancer related to the risk T allele (T vs. C: OR 1.11, 95 % CI 1.05-1.17).
|
26206751 |
2015 |
|
Thyroid carcinoma
|
|
0.850 |
GeneticVariation
|
BEFREE |
Our result demonstrated that rs9442</span>89 polymorphism on 14q13.3 is a low penetrant risk factor for developing TC.
|
25552255 |
2015 |
|
Thyroid carcinoma
|
|
0.850 |
GeneticVariation
|
BEFREE |
Five single nucleotide polymorphisms (SNPs) were previously reported to be associated with thyroid cancer in European populations in two genome-wide association studies (GWAS): rs965513 (9q22.33), rs944289 (14q13.3), rs116909374 (14q13.3), rs966423 (2q35) and rs2439302 (8p12).
|
23847140 |
2013 |
|
Thyroid carcinoma
|
|
0.850 |
GeneticVariation
|
BEFREE |
Five single nucleotide polymorphisms (SNPs) associated with thyroid cancer (TC) risk have been reported: rs2910164 (5q24); rs6983267 (8q24); rs965513 and rs1867277 (9q22); and rs944289 (14q13).
|
22282540 |
2012 |
|
Thyroid carcinoma
|
|
0.850 |
GeneticVariation
|
GWASCAT |
Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations.
|
19198613 |
2009 |
|
Thyroid carcinoma
|
|
0.850 |
GeneticVariation
|
GWASDB |
Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations.
|
19198613 |
2009 |
|
Nasopharyngeal carcinoma
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
|
20512145 |
2010 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two of them (rs944289 and rs116909374) are located at 14q13 making that locus an important target of research into the genetic predisposition to PTC.
|
30350351 |
2019 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
It was also shown that patient-related factors modify the predisposition to PTC by increasing the risk for rs944289 per year of age, and by enhancing the protective effect of the FOXE1 GGT haplotype in men.
|
28660995 |
2017 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Results of meta-analysis from the previous study and our new data indicated that variants of rs944289 and rs965513 might be the genetic susceptible factors both in Asians and Caucasians.We get the conclusion that mutations of TTF1 and TTF2 are significantly associated with an increasing risk of PTC in Chinese.
|
26356687 |
2015 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In PTC, significant associations were confirmed for rs965513 (p=4.21E-04; OR 1.587 [CI 1.235-2.000]) and rs944289 (p=0.003; OR 1.234 [CI 1.075-1.408]), newly found for rs2439302 (p=0.003; OR 1.266 [CI 1.087-1.493]) and rs1867277 (p=1.17E-04; OR 1.492 [CI 1.235-1.818]), and was not replicated for rs6983267 (p=0.082; OR 1.136 [CI 0.980-1.316]) in this series.
|
25562676 |
2015 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We previously showed that a long noncoding RNA gene, PTCSC3, located close to the variant rs944289 that predisposes to papillary thyroid carcinoma (PTC) might target the S100A4 gene.
|
26274343 |
2015 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, we found that rs944289 confers its risk, for both papillary thyroid carcinoma and follicular thyroid carcinoma when stratified by histological types of TC.
|
25552255 |
2015 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, rs944289</span> was associated with an increased risk of PTC in the Han population of Northern China, but no clear association was observed in either of the tag single nucleotide polymorphisms of NKX2-1.
|
24452548 |
2014 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, Rs965513 [A] and rs944289 [T] are risk factors of PTC.
|
24723258 |
2014 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Four candidate loci, rs965513 (9q22.33), rs944289 (14q13.3), rs966423 (2q35) and rs2439302 (8p12), identified by GWAS for PTC risk were confirmed in a Chinese population.
|
23847140 |
2013 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggest that SNP rs944289 predisposes to PTC through a previously uncharacterized, long intergenic noncoding RNA gene (PTCSC3) that has the characteristics of a tumor suppressor.
|
22586128 |
2012 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of both rs965513 (p=1.27×10(-4), OR=1.69, 95% CI 1.29 to 2.21) and rs944289 (p=0.0121, OR=1.21, 95% CI 1.04 to 1.39) with the risk of sporadic PTC was confirmed.
|
21730105 |
2011 |
|
Papillary thyroid carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Of interest, no association was obtained between radiation-related PTC and rs944289 (mhp = 0.17) at 14p13.3 which showed the second strongest association with sporadic PTC in Europeans.
|
20350937 |
2010 |
|
Malignant neoplasm of thyroid
|
|
0.050 |
GeneticVariation
|
BEFREE |
Overall, meta-analysis of rs944289</span> showed 1.11-fold increased risk of thyroid cancer related to the risk T allele (T vs. C: OR 1.11, 95 % CI 1.05-1.17).
|
26206751 |
2015 |
|
Malignant neoplasm of thyroid
|
|
0.050 |
GeneticVariation
|
BEFREE |
Association of rs944289, which was previously known to confer risk for thyroid cancer, with FA, and the correlation between PTCSC3 and NRG1 expression demonstrates that predisposing genetic factors are partly common for benign and malignant thyroid tumors, and imply broader roles of the pathways they underlie in thyroid tumorigenesis, not limited to carcinogenesis.
|
25562676 |
2015 |
|
Malignant neoplasm of thyroid
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our result demonstrated that rs9442</span>89 polymorphism on 14q13.3 is a low penetrant risk factor for developing TC.
|
25552255 |
2015 |
|
Thyroid Neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
Association of rs944289, which was previously known to confer risk for thyroid cancer, with FA, and the correlation between PTCSC3 and NRG1 expression demonstrates that predisposing genetic factors are partly common for benign and malignant thyroid tumors, and imply broader roles of the pathways they underlie in thyroid tumorigenesis, not limited to carcinogenesis.
|
25562676 |
2015 |
|
Thyroid Neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
Overall, meta-analysis of rs944289</span> showed 1.11-fold increased risk of thyroid cancer related to the risk T allele (T vs. C: OR 1.11, 95 % CI 1.05-1.17).
|
26206751 |
2015 |