|
Moyamoya disease 1
|
|
0.710 |
GeneticVariation
|
BEFREE |
Two novel SNPs in genes regulating homocysteine metabolism, rs9651118 in <i>MTHFR</i> (<i>P</i><sub>combined</sub>=2.49×10<sup>-19</sup>; odds ratio, 0.65) and rs117353193 in <i>TCN2</i> (<i>P</i><sub>combined</sub>=6.15×10<sup>-13</sup>; odds ratio, 1.43), were associated with high-serum homocysteine in MMD cases.
|
29273593 |
2018 |
|
Moyamoya Disease
|
|
0.710 |
GeneticVariation
|
BEFREE |
Two novel SNPs in genes regulating homocysteine metabolism, rs9651118 in <i>MTHFR</i> (<i>P</i><sub>combined</sub>=2.49×10<sup>-19</sup>; odds ratio, 0.65) and rs117353193 in <i>TCN2</i> (<i>P</i><sub>combined</sub>=6.15×10<sup>-13</sup>; odds ratio, 1.43), were associated with high-serum homocysteine in MMD cases.
|
29273593 |
2018 |
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, our findings suggested that MTHFR rs3753584, rs9651118 and rs1801133 polymorphisms may affect the risk of HCC in Chinese Han population.
|
31694048 |
2019 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We aimed to evaluate the associations of MTHFR (rs1801133, rs1801131, rs9651118), TCN2 (rs117353193) and RNF213 (rs9916351) with hypertension and blood pressure (BP).
|
31815282 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, <i>MTHFR</i> rs9651118 T>C polymorphism increased the risk of NSCLC in < 60 years, never smoking and BMI < 24 kg/m<sup>2</sup> subgroups.
|
29299150 |
2017 |
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a stratified analysis by CRC region, we found <i>MTHFR</i> rs3753584 T>C and rs9651118 T>C polymorphisms were associated with the increased risk of colon cancer.
|
28969008 |
2017 |
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a stratified analysis by CRC region, we found <i>MTHFR</i> rs3753584 T>C and rs9651118 T>C polymorphisms were associated with the increased risk of colon cancer.
|
28969008 |
2017 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, findings of the present study reveal that the tagging polymorphisms in <i>MTHFR</i> gene (rs3753584 T>C, rs9651118 T>C and rs4845882 G>A) are associated with the increased risk of CRC.
|
28969008 |
2017 |
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Also, a significant increase in the risk of CP was observed to be associated with the interactions of TNF-α rs1799724 and MTHFR rs9651118 (OR 2.75, 95 % CI 1.23-6.13).
|
26646537 |
2016 |
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, our data provide rationale to further validate the clinical utility of <i>MTHFR</i> rs9651118 as a biomarker for prognosis in prostate cancer.
|
27916838 |
2016 |
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, our data provide rationale to further validate the clinical utility of <i>MTHFR</i> rs9651118 as a biomarker for prognosis in prostate cancer.
|
27916838 |
2016 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Besides, MTHFR rs9651118 CC genotype was significantly associated with survival in breast cancer</span> cases (adjusted hazard ratio (HR) = 0.63, 95 % CI 0.40-0.99).
|
25566964 |
2015 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Besides, MTHFR rs9651118 CC genotype was significantly associated with survival in breast cancer</span> cases (adjusted hazard ratio (HR) = 0.63, 95 % CI 0.40-0.99).
|
25566964 |
2015 |
|
AIDS related complex
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype analyses revealed an adverse effect of the haplotype "C-A-T-C" (alleles in order of SNPs rs3737967, rs1801131, rs1801133 and rs9651118) on ARC risk (OR = 1.55, P = 0.003).
|
26689687 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype analysis also showed that MTHFR CTCCGA haplotype (rs12121543-rs13306553-rs9651118-rs1801133-rs2274976-rs1801131) had significant reduced risk of T2DM (adjusted OR = 0.71, 95% CI: 0.58-0.87, P = 0.001) compared with CTTTGA haplotype.
|
25165408 |
2014 |
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results demonstrated that MTHFR rs1801133 C>T was associated with the risk of ESCC; however, MTHFR rs4845882 G>A and rs4846048 A>G SNPs were associated with the decreased risk of ESCC, and MTHFR rs3753584 A>G and rs9651118 T>C SNPs were not associated with ESCC risk.
|
24687778 |
2014 |
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
SNPs in MTRR (rs13162612; OR = 0.25; 95% CI: 0.11-0.58; rs10512948; OR = 0.61; 95% CI: 0.41-0.90; rs2924471; OR = 3.31; 95% CI: 1.66-6.59), and MTHFR (rs9651118; OR = 0.63; 95% CI: 0.43-0.95) and three SNP*nutrient interactions (choline*rs10475407; OR = 1.62; 95% CI: 1.11-2.42; choline*rs11134290; OR = 0.51; 95% CI: 0.27-0.92; and riboflavin*rs8767412; OR = 0.40; 95% CI: 0.15-0.95) were associated with lung cancer risk in never smokers.
|
23372658 |
2013 |
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
SNPs in MTRR (rs13162612; OR = 0.25; 95% CI: 0.11-0.58; rs10512948; OR = 0.61; 95% CI: 0.41-0.90; rs2924471; OR = 3.31; 95% CI: 1.66-6.59), and MTHFR (rs9651118; OR = 0.63; 95% CI: 0.43-0.95) and three SNP*nutrient interactions (choline*rs10475407; OR = 1.62; 95% CI: 1.11-2.42; choline*rs11134290; OR = 0.51; 95% CI: 0.27-0.92; and riboflavin*rs8767412; OR = 0.40; 95% CI: 0.15-0.95) were associated with lung cancer risk in never smokers.
|
23372658 |
2013 |
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
SNPs in MTRR (rs13162612; OR = 0.25; 95% CI: 0.11-0.58; rs10512948; OR = 0.61; 95% CI: 0.41-0.90; rs2924471; OR = 3.31; 95% CI: 1.66-6.59), and MTHFR (rs9651118; OR = 0.63; 95% CI: 0.43-0.95) and three SNP*nutrient interactions (choline*rs10475407; OR = 1.62; 95% CI: 1.11-2.42; choline*rs11134290; OR = 0.51; 95% CI: 0.27-0.92; and riboflavin*rs8767412; OR = 0.40; 95% CI: 0.15-0.95) were associated with lung cancer risk in never smokers.
|
23372658 |
2013 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, confirmatory analyses of three tagging SNPs (rs1801133, rs17037396, and rs9651118) and the top SNP (rs17421511) for the imputation results (patients with schizophrenia = 797, control subjects = 1025) failed to replicate the haplotypic analysis and the imputation results.
|
20692813 |
2010 |