rs9930506, FTO

N. diseases: 16
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Obesity
CUI: C0028754
Disease: Obesity
0.760 GeneticVariation BEFREE The presence of the risk allele (G) of FTO rs9930506 was not associated with an increased risk of obesity. 30141234 2018
Obesity
CUI: C0028754
Disease: Obesity
0.760 GeneticVariation BEFREE This association, which was detected for the first time in this population, suggests that FTO rs9930506 is a predisposition marker to obesity in the Greek adults, but the results should be taken cautiously due to the limitation of the relatively small sample size of the subjects. 28257836 2017
Obesity
CUI: C0028754
Disease: Obesity
0.760 GeneticVariation BEFREE An association between the rs9930506 polymorphism and obesity was determined using codominant, dominant, and recessive models. 27241640 2016
Obesity
CUI: C0028754
Disease: Obesity
0.760 GeneticVariation BEFREE HTR2C, LEP, FTO and TBC1D1 represented the top genes for weight gain during treatment with a SGAP and/or MS. A genome-wide signal (FTO rs9930506) associated previously with obesity was associated with psychotropic-induced weight gain. 25946404 2015
Obesity
CUI: C0028754
Disease: Obesity
0.760 GeneticVariation BEFREE The risk alleles for obesity ("A" allele for the rs9939609 FTO variant and "G" allele for the rs9930506 FTO variant) were associated with low weight at birth. 25539997 2014
Obesity
CUI: C0028754
Disease: Obesity
0.760 GeneticVariation GWASDB Genome-wide population-based association study of extremely overweight young adults--the GOYA study. 21935397 2011
Obesity
CUI: C0028754
Disease: Obesity
0.760 GeneticVariation BEFREE In this study, we examined the association between three FTO variants (rs8050136, rs9939609, and rs9930506) and obesity and related traits in a population-based study of 3,210 unrelated Chinese Han subjects from Shanghai and Beijing. 17959933 2008
Body mass index
CUI: C1305855
Disease: Body mass index
0.700 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
Body mass index procedure
CUI: C0005893
Disease: Body mass index procedure
0.700 GeneticVariation GWASDB Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity. 24064335 2014
Finding of body mass index
CUI: C0578022
Disease: Finding of body mass index
0.700 GeneticVariation GWASDB Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity. 24064335 2014
Waist Circumference
CUI: C0455829
Disease: Waist Circumference
0.700 GeneticVariation GWASDB NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. 19557197 2009
Waist-Hip Ratio
CUI: C0205682
Disease: Waist-Hip Ratio
0.700 GeneticVariation GWASCAT Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. 17658951 2007
Body mass index
CUI: C1305855
Disease: Body mass index
0.700 GeneticVariation GWASCAT Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. 17658951 2007
Body Weight
CUI: C0005910
Disease: Body Weight
0.700 GeneticVariation GWASCAT Within the FTO gene, rs9930506 showed the strongest association with BMI (p = 8.6 x10(-7)), hip circumference (p = 3.4 x 10(-8)), and weight (p = 9.1 x 10(-7)). 17658951 2007
Polysomnography
CUI: C0162701
Disease: Polysomnography
0.700 GeneticVariation GWASDB Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. 17658951 2007
Polycystic Ovary Syndrome
CUI: C0032460
Disease: Polycystic Ovary Syndrome
0.010 GeneticVariation BEFREE We investigated the association between single nucleotide polymorphisms (SNPs) in the fat mass and obesity associated (FTO) gene (rs9926289 A/G, rs79206939 A/G, rs9930506 A/G, rs8050136 A/C, and rs1588413 C/T) and polycystic ovary syndrome (PCOS), as well as outcomes of in vitro fertilization (IVF). 29463151 2018
Acromegaly
CUI: C0001206
Disease: Acromegaly
0.010 GeneticVariation BEFREE Aim of this study was to investigate the allele frequencies of two FTO gene polymorphisms: rs9939609 and rs9930506 in patients with acromegaly and to examine the association of FTO gene polymorphisms with BMI and selected metabolic parameters. 28913579 2018
Diabetes
CUI: C0011847
Disease: Diabetes
0.010 GeneticVariation BEFREE No statistically significant difference was shown between the examined FTO polymorphism (rs9939609, rs1421085, and rs9930506) distribution between the subjects diagnosed with diabetes < 40 years , 40-60 years, and > 60 years old. 28585683 2017
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.010 GeneticVariation BEFREE No statistically significant difference was shown between the examined FTO polymorphism (rs9939609, rs1421085, and rs9930506) distribution between the subjects diagnosed with diabetes < 40 years , 40-60 years, and > 60 years old. 28585683 2017
Obesity, Morbid
CUI: C0028756
Disease: Obesity, Morbid
0.010 GeneticVariation BEFREE We studied the effect of sleeve gastrectomy and the influence of FTO rs9930506 polymorphism on Tie-2, angiopoietin-1 and angiopoietin-2 expression in morbid obesity. 27581034 2016
Non-alcoholic Fatty Liver Disease
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
0.010 GeneticVariation BEFREE Our aim was to identify whether the obesity-susceptible gene variants (rs9939609, rs9930506, and rs4783819 in fat mass and obesity-associated gene (FTO); rs12970134 and rs17782313 in melanocortin-4 receptor gene (MC4R); and rs7566605, rs13428113, and rs9308762 in insulin-induced gene 2 [INSIG2]) were associated with NAFLD. 24458218 2014
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.010 GeneticVariation BEFREE Two hundred and fifty drug naïve, Chinese Han patients with first-episode schizophrenia were enrolled in the study, and genotyped for four single nucleotide polymorphisms (SNPs rs9939609, rs8050136, rs1421085 and rs9930506) by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct sequencing. 25278160 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE None of the variants including previously reported intron 1 variants (rs1421085, rs8050136, rs9939609 and rs9930506) showed body mass index (BMI)-dependent/independent association with type 2 diabetes. 21814223 2011