|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
We confirmed the rs9939609 A-allele as a risk factor for early onset obesity whereas its impact on weight loss or on serum levels of glucose, triglycerides and cholesterol could not be detected in our samples.
|
18799002 |
2008 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The variant rs9939609 showed significant association with risk of obesity [OR = 1.21, P = 2.5 × 10(-3)] and its measures BMI, weight, waist circumference and hip circumference [β range = 0.11 to 0.14 Z-score units; P range = 1.3 × 10(-4) to 1.6 × 10(-7)] in children.
|
23091647 |
2012 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Here, we investigated the involvement of FTO rs9939609 and MC4R rs17782313 polymorphisms in the development of obesity.
|
19668254 |
2009 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The obesity risk alleles of BDNF rs925946 and FTO rs9939609 were related to a lower calcium intake (P = .001 and .037).
|
26162542 |
2015 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
We focused on rs7185735 and rs9939609, 2 common single nucleotide polymorphisms of the fat mass and obesity-associated (FTO) gene reported to be associated with obesity.
|
29334686 |
2019 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The FTO gene, rs9939609, was associated with obesity, and the association was evident in subjects with low-PA, suggesting a PA-dependent association.
|
20051647 |
2010 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The common polymorphism rs9939609 of the fat mass and obesity-associated gene (FTO) is strongly associated with obesity, but the biological function is still unknown.
|
20948226 |
2010 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs9939609, within the FTO locus and obesity as a consequence of a genome wide association (GWA) study of type 2 diabetes in adults.
|
18335027 |
2008 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Fat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with bulimia nervosa and anorexia nervosa.
|
22797368 |
2012 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
However, rs1421085, rs8050136 and rs9939609 were associated with obesity status and measures of obesity (BMI, waist circumference and waist-to-hip ratio) in stage 2 and combined study population.
|
21814223 |
2011 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The association between FTO SNP rs9939609 and obesity risk may decline at older age.
|
18647953 |
2008 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Findings of the present study highlight the association between FTO rs9939609 and obesity or body fat indices in girls but not in boys.
|
31444941 |
2019 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
We found no increased risk of obesity and no association with BMI at any age with the FTO rs9939609 variant.
|
20003232 |
2009 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our findings indicate that rs9939609 in the FTO gene is associated with pancreatic cancer risk in Japanese subjects, possibly through a mechanism that is independent of obesity.
|
23835106 |
2013 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The common SNP (rs9939609) in the FTO gene modifies the association between obesity and high blood pressure in Chinese children.
|
23111453 |
2013 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The FTO gene polymorphism rs9939609 is associated with obesity and disability in multiple sclerosis patients.
|
31836807 |
2019 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
This study reveals interactions between rs9939609 and PA on obesity indices in Portuguese young adults, suggesting a change in the different body components (lean and fat mass) depending on the FTO genotypes.
|
25809737 |
2016 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our findings indicate that the two variants (rs9939609 and rs8050136) in the FTO gene contribute to obesity and T2D in the Asian populations.
|
20057365 |
2010 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
This finding was evident only in nonobese subjects.The FTO rs9939609 polymorphism is an independent risk factor for obesity and also for biological aging in the nonobese population.
|
28746203 |
2017 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Of interest, a markedly lower frequency of the FTO rs9939609 obesity risk A-allele was found in BED patients (0.290) in relation to the control group (0.402).
|
30677719 |
2019 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Association between overweight and obesity in schoolchildren with rs9939609 polymorphism (FTO) and family history for obesity.
|
27154418 |
2017 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recently, we reported that having depression moderates the effect of the <i>FTO</i> gene, suggesting its implication in the association between depression and obesity.<b>Aims</b>To confirm these findings by investigating the <i>FTO</i> polymorphism rs9939609 in new cohorts, and subsequently in a meta-analysis.<b>Method</b>The sample consists of 6902 individuals with depression and 6799 controls from three replication cohorts and two original discovery cohorts.
|
28642257 |
2017 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The FTO rs9939609 polymorphism and obesity risk in teens: Evidence-based meta-analysis.
|
30104138 |
2019 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The obesity risk allele at FTO SNP rs9939609 was not associated with BMI-SDS reduction during the lifestyle intervention (p = 0.622), but with weight regain 1 year after end of the intervention in multiple linear regression analyses adjusted for age, sex, pubertal stage, and baseline BMI-SDS (Bonferroni corrected p = 0.002).
|
24819256 |
2014 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
A region in the first intron of the fat mass- and obesity-associated (FTO) gene, encompassing markers rs9939973, rs8050136, and rs9939609, has been consistently associated with obesity and body mass index (BMI) in different populations.
|
26529281 |
2015 |