|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
In European populations, common variants (rs1421085-C, rs17817449-G, and rs9939609-A) in the fat mass and obesity (FTO associated) were recently found to be associated with body mass index (BMI) or obesity.
|
17928949 |
2007 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
We confirmed the rs9939609 A-allele as a risk factor for early onset obesity whereas its impact on weight loss or on serum levels of glucose, triglycerides and cholesterol could not be detected in our samples.
|
18799002 |
2008 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs9939609, within the FTO locus and obesity as a consequence of a genome wide association (GWA) study of type 2 diabetes in adults.
|
18335027 |
2008 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The association between FTO SNP rs9939609 and obesity risk may decline at older age.
|
18647953 |
2008 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs9939609 T>A single-nucleotide polymorphism (SNP) in the FTO gene has previously been found to be associated with obesity in European Caucasian samples.
|
18339204 |
2008 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
A case-control association analysis revealed that 15 SNPs, including rs9939609 and rs1121980, in a linkage disequilibrium (LD) block of approximately 50 kb demonstrated significant associations with obesity; rs1558902 was most significantly associated with obesity.
|
18379722 |
2008 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.
|
18682847 |
2008 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
In this study, we examined the association between three FTO variants (rs8050136, rs9939609, and rs9930506) and obesity and related traits in a population-based study of 3,210 unrelated Chinese Han subjects from Shanghai and Beijing.
|
17959933 |
2008 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004).
|
18853134 |
2008 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Among the 19 SNPs, the rs9939609 A allele was strongly associated with obesity (P = 7.0 x 10(-4)) and BMI (P = 0.0024) in the Chinese population.
|
18487448 |
2008 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Gender differences were also found in the associations of the FTO rs9939609 with obesity related traits such as insulin sensitivity and plasma glucose.
|
18249188 |
2008 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Here, we investigated the involvement of FTO rs9939609 and MC4R rs17782313 polymorphisms in the development of obesity.
|
19668254 |
2009 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
We found no increased risk of obesity and no association with BMI at any age with the FTO rs9939609 variant.
|
20003232 |
2009 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Children with the FTO (rs9939609) variant that increases the risk of obesity may have a higher susceptibility to the effects of DED because their internal appetite control system is compromised.
|
19259258 |
2009 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
To further investigate a common variant (rs9939609) in the fat mass- and obesity-associated gene (FTO), which recent genome-wide association studies have shown to be associated with body mass index (BMI) and obesity.
|
19030008 |
2009 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Meta-analysis suggested that rs9939609 A allele was more significantly associated with obesity risk than T allele (3 studies / 004 cases and 4544 control subjects): random effect odds ratio (OR)=1.28, 95%CI=1.05 and 1.55, P heterogeneity =0.05, I2=66.6%.
|
20337217 |
2009 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The FTO gene rs9939609 obesity-risk allele and loss of control over eating.
|
19828706 |
2009 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The present report does not support the notion that physical activity modifies the effects of the FTO rs9939609 variant on obesity risk in the non-diabetic Swedish or Finnish adults studied here.
|
19373445 |
2009 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, the role of the A allele of the FTO rs9939609 polymorphism on the risk of obesity and type 2 diabetes mellitus was confirmed in the French MONICA Study.
|
19375760 |
2009 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our results show: (1) A strong association between rs9939609 SNP of the FTO gene variant and obesity in Spanish morbidly obese adult patients; (2) positive correlations between FTO mRNA and leptin, perilipin, and visfatin gene expressions in subcutaneous adipose tissue; (3) FTO and perilipin gene expressions were positively correlated in visceral fat depot.
|
18855084 |
2009 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The minor A-allele of rs9939609 was associated with an increased odds ratio (OR) for obesity [OR 1.51, 95% confidence interval (CI) 1.10-2.12] as compared to the TT genotype.
|
18616701 |
2009 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recent studies identified the rs9939609 A-allele of the FTO (fat mass and obesity associated) gene as being associated with obesity and type 2 diabetes.
|
18984658 |
2009 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The FTO gene, rs9939609, was associated with obesity, and the association was evident in subjects with low-PA, suggesting a PA-dependent association.
|
20051647 |
2010 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The common polymorphism rs9939609 of the fat mass and obesity-associated gene (FTO) is strongly associated with obesity, but the biological function is still unknown.
|
20948226 |
2010 |
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our findings indicate that the two variants (rs9939609 and rs8050136) in the FTO gene contribute to obesity and T2D in the Asian populations.
|
20057365 |
2010 |