Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 656 3066
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 747 2600
LDLR P01130 low density lipoprotein receptor 9.8E-24 0.449 0.885 336 1434
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 684 974
NF1 P21359 neurofibromin 1 Enzyme modulator 0.90 0.440 0.885 380 935
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808 490 777
MLH1 P40692 mutL homolog 1 Nucleic acid binding 3.4E-05 0.399 0.808 526 757
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 703 681
MSH6 P52701 mutS homolog 6 Nucleic acid binding 3.7E-05 0.462 0.731 296 642
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769 260 410
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 1349 384
DMD P11532 dystrophin 1.00 0.423 0.923 484 345
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923 469 292
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808 244 282
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808 297 261
ALDH1A2 O94788 aldehyde dehydrogenase 1 family member A2 Enzyme 0.36 0.578 0.692 109 243
BRIP1 Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 6.2E-17 0.507 0.731 194 242
GALT P07902 galactose-1-phosphate uridylyltransferase Enzyme 2.1E-06 0.612 0.654 87 224
FANCA O15360 FA complementation group A 1.6E-68 0.505 0.731 211 206
PTCH1 Q13635 patched 1 1.00 0.398 0.885 604 194
NBN O60934 nibrin Nucleic acid binding 2.2E-16 0.467 0.808 291 194
DICER1 Q9UPY3 dicer 1, ribonuclease III Enzyme 1.00 0.446 0.846 302 191
CDH1 P12830 cadherin 1 0.15 0.401 0.808 508 187