Source: ANIMAL_MODELS

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 101
IL6 P05231 interleukin 6 0.32 0.248 0.962 54
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 42
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 62
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 12
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 45
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 94
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 47
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 21
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 44
LEP P41159 leptin 0.46 0.349 0.846 34
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846 14
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 1
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 23
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 48
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 60
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 55
GH1 P01241 growth hormone 1 Signaling 3.0E-02 0.373 0.923 9
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 4.6E-09 0.376 0.885 26
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 72
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 23
MAPK3 P27361 mitogen-activated protein kinase 3 Kinase 3.7E-02 0.379 0.885 11