Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 138 5
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 137 3
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 115 105
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 103 4
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 95 596
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 92 30
CDH1 P12830 cadherin 1 0.15 0.401 0.808 73 158
NOTCH2 Q04721 notch receptor 2 1.00 0.441 0.808 60 28
APOA1 P02647 apolipoprotein A1 5.5E-04 0.429 0.885 59 21
PAX6 P26367 paired box 6 1.00 0.450 0.769 55 109
CDKN1B P46527 cyclin dependent kinase inhibitor 1B 0.62 0.409 0.769 54 17
ARID1A O14497 AT-rich interaction domain 1A 1.00 0.455 0.846 48 17
HSPB1 P04792 heat shock protein family B (small) member 1 2.8E-07 0.436 0.808 47 26
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 46 64
CYP2A6 P11509 cytochrome P450 family 2 subfamily A member 6 5.4E-09 0.556 0.731 44 3
PRNP F7VJQ1 P04156 prion protein 6.3E-04 0.445 0.923 43 30
APEX1 P27695 apurinic/apyrimidinic endodeoxyribonuclease 1 1.9E-07 0.458 0.846 38 1
DES P17661 desmin 8.8E-03 0.460 0.846 36 56
HSPD1 P10809 heat shock protein family D (Hsp60) member 1 0.99 0.432 0.808 35 5
KRT8 P05787 keratin 8 2.4E-08 0.517 0.654 35 7
CDKN1A P38936 cyclin dependent kinase inhibitor 1A 1.9E-03 0.403 0.769 34 6