Source: GENOMICS_ENGLAND

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 19
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 6
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962 6
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 4
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 4
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 4
RAC1 P63000 Rac family small GTPase 1 Enzyme modulator 0.76 0.429 0.962 3
FN1 P02751 fibronectin 1 Signaling 1.4E-03 0.365 0.962 2
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 2
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 2
ALB P02768 albumin Transporter 0.64 0.317 0.962 1
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 1
FCGR3A P08637 Fc fragment of IgG receptor IIIa Cell adhesion 3.7E-06 0.432 0.962 1
IFNG P01579 interferon gamma 0.47 0.288 0.962 1
MTCO2P12 MT-CO2 pseudogene 12 0.368 0.962 1
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 23
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 14
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 12
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 11
CTLA4 P16410 cytotoxic T-lymphocyte associated protein 4 0.94 0.369 0.923 10
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 8
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 7
FLNB O75369 filamin B 6.1E-10 0.458 0.923 6
IL1RN P18510 interleukin 1 receptor antagonist 3.1E-02 0.373 0.923 6