Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 184 9
CSF3 P09919 colony stimulating factor 3 0.38 0.377 0.885 168 2
IFNG P01579 interferon gamma 0.47 0.288 0.962 167 1
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 138 5
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 137 3
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 130 54
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 119 12
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 115 105
LEP P41159 leptin 0.46 0.349 0.846 114 3
BCHE P06276 butyrylcholinesterase 1.1E-13 0.447 0.923 108 98
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 103 4
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 95 5
CYP2D6 P10635 cytochrome P450 family 2 subfamily D member 6 1.1E-25 0.437 0.885 93 2
SPP1 P10451 secreted phosphoprotein 1 2.1E-06 0.353 0.885 81 1
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 78 47
CDH1 P12830 cadherin 1 0.15 0.401 0.808 73 158
PARP1 P09874 poly(ADP-ribose) polymerase 1 3.3E-04 0.389 0.923 62 3
NOTCH2 Q04721 notch receptor 2 1.00 0.441 0.808 60 28
CDKN1B P46527 cyclin dependent kinase inhibitor 1B 0.62 0.409 0.769 54 17
NQO1 P15559 NAD(P)H quinone dehydrogenase 1 1.2E-09 0.434 0.885 52 1
VIM P08670 vimentin 0.71 0.372 0.846 51 4