Source: HPO

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 128
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 255
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 187
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 254
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 337
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 73
FGFR1 P11362 fibroblast growth factor receptor 1 Kinase 1.00 0.362 0.885 303
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 147
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 66
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 67
EZH2 Q15910 enhancer of zeste 2 polycomb repressive complex 2 subunit Epigenetic regulator 1.00 0.376 0.885 83
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 176
BRCA2 P51587 BRCA2 DNA repair associated Nucleic acid binding 2.4E-25 0.379 0.846 140
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 301
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 154
SLC2A1 P11166 solute carrier family 2 member 1 Transporter 0.99 0.388 0.808 117
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 186
FGFR3 P22607 fibroblast growth factor receptor 3 Kinase 1.6E-05 0.391 0.846 264
RET P07949 ret proto-oncogene Kinase 1.00 0.392 0.885 141
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 205
TWIST1 Q15672 twist family bHLH transcription factor 1 Transcription factor 0.34 0.397 0.846 117
PTCH1 Q13635 patched 1 1.00 0.398 0.885 143
IGF1R P08069 insulin like growth factor 1 receptor Kinase 0.97 0.399 0.885 58
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 132