Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 285 1
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
IFNA2 P01563 interferon alpha 2 0.442 0.885 170 0
CSF3 P09919 colony stimulating factor 3 0.38 0.377 0.885 168 2
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 164 35
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 138 9
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 124 58
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 120 21
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 119 12
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 115 105
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 113 95
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 109 1
BAP1 Q92560 BRCA1 associated protein 1 Enzyme 0.99 0.454 0.731 108 72
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 103 4
ACHE P22303 acetylcholinesterase (Cartwright blood group) Enzyme 1.00 0.445 0.885 100 3
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 98 8
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 91 10
NOTCH1 P46531 notch receptor 1 1.00 0.369 0.885 78 47
IL2 P60568 interleukin 2 0.48 0.336 0.885 75 3
TSC1 Q92574 TSC complex subunit 1 1.00 0.440 0.808 74 144
CDH1 P12830 cadherin 1 0.15 0.401 0.808 73 158