Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 285 1
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 182 355
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 179 27
CSF3 P09919 colony stimulating factor 3 0.38 0.377 0.885 168 2
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 164 35
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 141 11
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 138 40
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 124 58
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 120 21
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 113 95
OXT P01178 oxytocin/neurophysin I prepropeptide Signaling 0.71 0.615 0.423 110 1
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 103 4
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962 103 3
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 96 6
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 91 10
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 90 28
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 89 2
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 84 4
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 80 3
CDH1 P12830 cadherin 1 0.15 0.401 0.808 73 158
ESR2 Q92731 estrogen receptor 2 Nuclear receptor 4.5E-08 0.400 0.923 73 19
TGFBR2 P37173 transforming growth factor beta receptor 2 Kinase 0.13 0.413 0.846 71 57