Source: CLINVAR

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
ABCC8 Q09428 ATP binding cassette subfamily C member 8 Transporter 8.0E-24 0.474 0.846 32 164
WFS1 O76024 wolframin ER transmembrane glycoprotein 1.6E-38 0.528 0.846 24 29
TRNL1 tRNA 0.534 0.731 22 11
KCNJ11 Q14654 potassium inwardly rectifying channel subfamily J member 11 Ion channel 1.1E-02 0.529 0.615 15 55
CERKL Q49MI3 ceramide kinase like 9.8E-25 0.678 0.308 12 17
GCK P35557 glucokinase Kinase 0.63 0.523 0.808 10 137
HNF1A P20823 HNF1 homeobox A Nucleic acid binding 0.96 0.478 0.846 10 52
HNF4A P41235 hepatocyte nuclear factor 4 alpha Nuclear receptor 0.15 0.461 0.808 9 24
WRN Q14191 WRN RecQ like helicase Enzyme 2.6E-34 0.524 0.808 8 57
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 8 22
INSR P06213 insulin receptor Kinase 3.6E-05 0.432 0.846 7 34
SLC2A2 P11168 solute carrier family 2 member 2 Transporter 3.4E-08 0.572 0.692 7 17
HNF1B P35680 HNF1 homeobox B Nucleic acid binding 1.00 0.473 0.808 5 35
PDX1 P52945 pancreatic and duodenal homeobox 1 1.8E-02 0.530 0.654 5 12
RBPJ Q06330 recombination signal binding protein for immunoglobulin kappa J region Nucleic acid binding 1.00 0.518 0.808 4 6
AKT2 P31751 AKT serine/threonine kinase 2 Kinase 0.64 0.474 0.769 4 4
IRS1 P35568 insulin receptor substrate 1 2.4E-02 0.488 0.769 3 3
LIPC P11150 lipase C, hepatic type Enzyme 3.3E-07 0.585 0.654 3 3
NEUROD1 Q13562 neuronal differentiation 1 Enzyme 0.77 0.543 0.808 3 3
CAPN10 Q9HC96 calpain 10 Enzyme 6.9E-13 0.621 0.577 2 4
PAX4 O43316 paired box 4 4.2E-04 0.644 0.423 2 3
ALDH1A2 O94788 aldehyde dehydrogenase 1 family member A2 Enzyme 0.36 0.578 0.692 2 1
MTNR1B P49286 melatonin receptor 1B G-protein coupled receptor 6.5E-04 0.588 0.731 1 4
TCF7L2 Q9NQB0 transcription factor 7 like 2 1.00 0.485 0.846 1 2