Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 86
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 58
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 48
CASP9 P55211 caspase 9 Enzyme 7.4E-06 0.458 0.808 37
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 32
AGTR1 P30556 angiotensin II receptor type 1 G-protein coupled receptor 5.3E-04 0.423 0.846 26
ANGPT2 O15123 angiopoietin 2 Signaling 0.83 0.410 0.846 25
AGTR2 P50052 angiotensin II receptor type 2 G-protein coupled receptor 8.2E-03 0.496 0.808 22
LIPC P11150 lipase C, hepatic type Enzyme 3.3E-07 0.585 0.654 19
LPL P06858 lipoprotein lipase Enzyme 1.3E-09 0.474 0.808 16
TRPC6 Q9Y210 transient receptor potential cation channel subfamily C member 6 Ion channel 3.0E-07 0.514 0.692 8
VLDLR P98155 very low density lipoprotein receptor 2.0E-11 0.558 0.692 5
ACTR3 P61158 actin related protein 3 Cellular structure 1.00 0.686 0.385 3
PIAS1 O75925 protein inhibitor of activated STAT 1 1.00 0.633 0.731 1