Source: ANIMAL_MODELS

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 101
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 72
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 64
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 45
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 42
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 39
AGTR1 P30556 angiotensin II receptor type 1 G-protein coupled receptor 5.3E-04 0.423 0.846 34
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 31
IGF2 P01344 insulin like growth factor 2 4.4E-02 0.390 0.885 28
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 23
AGTR2 P50052 angiotensin II receptor type 2 G-protein coupled receptor 8.2E-03 0.496 0.808 22
EP300 Q09472 E1A binding protein p300 1.00 0.459 0.846 21
BMP4 P12644 bone morphogenetic protein 4 Signaling 0.96 0.422 0.808 20
ATP7A Q04656 ATPase copper transporting alpha Transporter 1.00 0.494 0.769 13
PDGFRA P16234 platelet derived growth factor receptor alpha Kinase 1.00 0.415 0.808 13
RXRA P19793 retinoid X receptor alpha Nuclear receptor 1.00 0.543 0.769 13
LRP1 Q07954 LDL receptor related protein 1 1.00 0.482 0.769 12
GATA4 P43694 GATA binding protein 4 0.49 0.458 0.846 11
ELN P15502 elastin 2.1E-14 0.415 0.885 8
IGFBP3 P17936 insulin like growth factor binding protein 3 Enzyme modulator 0.91 0.439 0.808 8
PAX3 P23760 paired box 3 0.24 0.481 0.769 8
FREM1 Q5H8C1 FRAS1 related extracellular matrix 1 1.6E-52 0.633 0.423 5
MYOD1 P15172 myogenic differentiation 1 Transcription factor 0.15 0.569 0.654 5
CBL P22681 Cbl proto-oncogene Enzyme 6.1E-04 0.527 0.769 4