Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 285 1
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 241 7
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 184 9
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 182 355
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 179 27
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 171 2
INS P01308 insulin 0.30 0.445 0.923 157 34
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 151 0
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 147 48
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 146 14
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 141 11
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 138 9
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 138 5
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 137 3
PLAT P00750 plasminogen activator, tissue type Enzyme 5.7E-05 0.445 0.885 136 1
DRD2 P14416 dopamine receptor D2 G-protein coupled receptor 0.75 0.436 0.846 133 7
ALB P02768 albumin Transporter 0.64 0.317 0.962 123 9
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 119 12
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 115 30