Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 58
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 40
BECN1 Q14457 beclin 1 Enzyme modulator 0.94 0.432 0.846 39
ANXA1 P04083 annexin A1 1.2E-07 0.442 0.885 30
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 28
CX3CL1 P78423 C-X3-C motif chemokine ligand 1 Signaling 0.61 0.478 0.808 27
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 27
ANGPT2 O15123 angiopoietin 2 Signaling 0.83 0.410 0.846 25
TNFRSF1A P19438 TNF receptor superfamily member 1A 0.99 0.409 0.923 23
LIPC P11150 lipase C, hepatic type Enzyme 3.3E-07 0.585 0.654 19
GJB2 P29033 gap junction protein beta 2 Cell-cell junction 6.6E-16 0.441 0.846 18
MUC2 Q02817 mucin 2, oligomeric mucus/gel-forming Enzyme modulator 9.4E-10 0.486 0.808 18
ABAT P80404 4-aminobutyrate aminotransferase Enzyme 6.3E-03 0.628 0.538 16
MAP1LC3A Q9H492 microtubule associated protein 1 light chain 3 alpha Cellular structure 2.8E-02 0.610 0.654 15
PTK2 Q05397 protein tyrosine kinase 2 Kinase 1.00 0.497 0.808 15
AKT2 P31751 AKT serine/threonine kinase 2 Kinase 0.64 0.474 0.769 12
CRHR2 Q13324 corticotropin releasing hormone receptor 2 G-protein coupled receptor 8.5E-17 0.584 0.731 10
MMP14 P50281 matrix metallopeptidase 14 Enzyme 1.00 0.447 0.769 10
PTGES O14684 prostaglandin E synthase 0.71 0.540 0.769 10
THBD P07204 thrombomodulin 5.4E-02 0.457 0.769 10
PRKCA P17252 protein kinase C alpha Kinase 0.37 0.440 0.846 9
CALCA P01258 P06881 calcitonin related polypeptide alpha Signaling 1.6E-02 0.416 0.923 8
HTR1B P28222 5-hydroxytryptamine receptor 1B G-protein coupled receptor 0.19 0.551 0.769 8
ITGAV P06756 integrin subunit alpha V 2.3E-04 0.526 0.769 5