Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1511 83
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 1314 146
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1250 33
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 1228 107
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 1213 54
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885 1119 24
PIK3CG P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Kinase 1.4E-06 0.320 0.885 1101 12
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 1083 13
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 1059 13
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923 774 33
PTPN11 Q06124 protein tyrosine phosphatase non-receptor type 11 1.00 0.385 0.923 702 98
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 698 29
EPHB2 P29323 EPH receptor B2 Kinase 1.00 0.374 0.846 649 19
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 611 17
IGF2 P01344 insulin like growth factor 2 4.4E-02 0.390 0.885 604 19
ELN P15502 elastin 2.1E-14 0.415 0.885 545 61
PDGFRB P09619 platelet derived growth factor receptor beta Kinase 0.90 0.416 0.846 492 30
RAF1 P04049 Raf-1 proto-oncogene, serine/threonine kinase Kinase 0.85 0.418 0.885 470 52
CDK4 P11802 cyclin dependent kinase 4 Kinase 6.3E-02 0.412 0.808 433 8
IL23A Q9NPF7 interleukin 23 subunit alpha Signaling 0.36 0.415 0.846 427 2
MAP2K7 O14733 mitogen-activated protein kinase kinase 7 Kinase 1.00 0.419 0.808 408 9
MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 Kinase 0.90 0.439 0.846 389 43
GLB1 P16278 galactosidase beta 1 Enzyme 7.9E-10 0.448 0.808 385 124