Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor signaling molecule 0.80 0.263 0.966 225
IL6 P05231 interleukin 6 0.34 0.287 0.966 177
VEGFA P15692 vascular endothelial growth factor A signaling molecule 2.7E-05 0.298 0.897 171
TP53 P04637 tumor protein p53 transcription factor 0.17 0.251 0.897 170
TGFB1 P01137 transforming growth factor beta 1 signaling molecule 0.17 0.336 0.931 156
MMP9 P14780 matrix metallopeptidase 9 hydrolase; protease 7.0E-18 0.339 0.862 149
IL10 P22301 interleukin 10 6.5E-03 0.320 0.931 134
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 oxidoreductase 1.00 0.338 0.897 118
IL1B P01584 interleukin 1 beta 0.13 0.312 0.931 111
MTHFR P42898 methylenetetrahydrofolate reductase 1.2E-09 0.354 0.828 111
CXCL8 P10145 C-X-C motif chemokine ligand 8 signaling molecule 0.342 0.862 100
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.38 0.321 0.828 95
MMP2 P08253 matrix metallopeptidase 2 hydrolase; protease 0.84 0.373 0.862 95
ACE P12821 angiotensin I converting enzyme hydrolase; protease 1.6E-37 0.367 0.897 94
IFNG P01579 interferon gamma 0.47 0.323 0.897 91
ICAM1 P05362 intercellular adhesion molecule 1 3.8E-02 0.386 0.897 89
HLA-DRB1 P01911 P01912 P04229 P13760 P13761 P20039 Q29974 Q30134 Q30167 Q5Y7A7 Q95IE3 Q9GIY3 Q9TQE0 major histocompatibility complex, class II, DR beta 1 defense/immunity protein 1.0E-03 0.347 0.897 88
CRP P02741 C-reactive protein 3.7E-03 0.399 0.862 85
EGFR P00533 epidermal growth factor receptor 0.50 0.325 0.862 85
APOE P02649 apolipoprotein E 1.7E-03 0.352 0.931 84
IL18 Q14116 interleukin 18 2.9E-02 0.404 0.862 84
BCL2 P10415 BCL2, apoptosis regulator signaling molecule 0.57 0.312 0.862 83
LEP P41159 leptin 0.39 0.400 0.793 77
FAS P25445 Fas cell surface death receptor 0.84 0.393 0.862 76