Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 2494 527
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 1511 83
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 1368 68
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 1250 33
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 1206 36
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 1110 39
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 985 137
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 715 92
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 698 29
SLC2A1 P11166 solute carrier family 2 member 1 Transporter 0.99 0.388 0.808 687 76
GH1 P01241 growth hormone 1 Signaling 3.0E-02 0.373 0.923 686 27
MECP2 P51608 methyl-CpG binding protein 2 Epigenetic regulator 0.89 0.414 0.846 664 387
FGFR3 P22607 fibroblast growth factor receptor 3 Kinase 1.6E-05 0.391 0.846 654 55
MPO P05164 myeloperoxidase Enzyme 7.1E-15 0.377 0.923 653 25
NRAS P01111 NRAS proto-oncogene, GTPase Enzyme modulator 0.49 0.390 0.808 611 17
PLG P00747 plasminogen Enzyme 1.0E-02 0.389 0.923 586 34
FLNA P21333 filamin A 1.00 0.419 0.846 571 85
CDH1 P12830 cadherin 1 0.15 0.401 0.808 508 187
WNK1 Q9H4A3 WNK lysine deficient protein kinase 1 Kinase 1.00 0.416 0.846 460 26
AVP P01185 arginine vasopressin Signaling 7.4E-02 0.437 0.846 454 27
CYP2D6 P10635 cytochrome P450 family 2 subfamily D member 6 1.1E-25 0.437 0.885 432 14
TBX1 O43435 T-box transcription factor 1 Transcription factor 0.84 0.433 0.808 417 14
ATRX P46100 ATRX chromatin remodeler 1.00 0.452 0.808 412 38
PRKN O60260 parkin RBR E3 ubiquitin protein ligase Enzyme 6.9E-07 0.431 0.846 409 88