×
Entrez Id: 1495
Gene Symbol: CTNNA1
CTNNA1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
×
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Hereditary Nonpolyposis Colorectal Neoplasms
0.900
Biomarker
CLINGEN
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.
8261515 1993
×
Entrez Id: 5395
Gene Symbol: PMS2
PMS2
Hereditary Nonpolyposis Colorectal Neoplasms
0.640
Biomarker
CLINGEN
Mutations of two PMS homologues in hereditary nonpolyposis colon cancer.
8072530 1994
×
Entrez Id: 2052
Gene Symbol: EPHX1
EPHX1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants.
7516776 1994
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
Hereditary Nonpolyposis Colorectal Neoplasms
0.640
Biomarker
CLINGEN
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells.
7604265 1995
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
Hereditary Nonpolyposis Colorectal Neoplasms
0.640
Biomarker
CLINGEN
Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.
7604264 1995
×
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
Hereditary Nonpolyposis Colorectal Neoplasms
0.900
Biomarker
CLINGEN
Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice.
8706033 1996
×
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA.
8805365 1996
×
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6.
8942985 1996
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
Hereditary Nonpolyposis Colorectal Neoplasms
0.640
Biomarker
CLINGEN
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer.
9354786 1997
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
Hereditary Nonpolyposis Colorectal Neoplasms
0.640
Biomarker
CLINGEN
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility.
9390556 1997
×
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases.
9736017 1998
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
E-cadherin germline mutations in familial gastric cancer.
9537325 1998
×
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
The murine gene p27Kip1 is haplo-insufficient for tumour suppression.
9823898 1998
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
Hereditary Nonpolyposis Colorectal Neoplasms
0.640
Biomarker
CLINGEN
HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions.
10545954 1999
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
Hereditary Nonpolyposis Colorectal Neoplasms
0.640
Biomarker
CLINGEN
Association of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations.
10521294 1999
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells.
10051639 1999
×
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells.
9926925 1999
×
Entrez Id: 999
Gene Symbol: CDH1
CDH1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer.
10072428 1999
×
Entrez Id: 9156
Gene Symbol: EXO1
EXO1
Hereditary Nonpolyposis Colorectal Neoplasms
0.310
Biomarker
CLINGEN
Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis.
10856833 2000
×
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.
10706084 2000
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
Hereditary Nonpolyposis Colorectal Neoplasms
0.640
Biomarker
CLINGEN
MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer.
11245474 2001
×
Entrez Id: 9156
Gene Symbol: EXO1
EXO1
Hereditary Nonpolyposis Colorectal Neoplasms
0.310
Biomarker
CLINGEN
HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes.
11429708 2001
×
Entrez Id: 2052
Gene Symbol: EPHX1
EPHX1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Distribution of microsomal epoxide hydrolase in humans: an immunohistochemical study in normal tissues, and benign and malignant tumours.
11758809 2001
×
Entrez Id: 580
Gene Symbol: BARD1
BARD1
Hereditary Nonpolyposis Colorectal Neoplasms
0.300
Biomarker
CLINGEN
Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1.
11498787 2001