Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Night-time restricted feeding normalises clock genes and Pai-1 gene expression in the db/db mouse liver. 15309293

2004
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice. 15885672

2005
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance. 17095713

2007
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells. 24332968

2014
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Prostaglandin transporter modulates wound healing in diabetes by regulating prostaglandin-induced angiogenesis. 22609345

2012
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy. 12651605

2003
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Diabetic neuropathy in the mutant mouse [C57BL/ks(db/db)]: a morphometric study. 6991317

1980
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. 16971655

2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Intraocular pressure in genetically distinct mice: an update and strain survey. 11532192

2001
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Diabetes-induced, progressive endometrial involution characterization of periluminal epithelial lipoatrophy. 12502493

2003
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. 15070774

2004
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Leptin increases axonal growth cone size in developing mouse cortical neurons by convergent signals inactivating glycogen synthase kinase-3beta. 16522636

2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. 15685168

2005
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Diabetes, a new mutation in the mouse. 5918576

1966
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Conditioned taste aversion learning in leptin-receptor-deficient db/db mice. 12932425

2003
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. 8177042

1994
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Primary myocardial disease in the diabetic mouse. An ultrastructural study. 431046

1979
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Myocardial infarction and heart failure in the db/db diabetic mouse. 16113078

2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice. 9299565

1997
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Anti-pancreatic immunity in genetically diabetic mice. 6339122

1983
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Studies in the diabetic mutant mouse. VI. Evolution of glomerular lesions and associated proteinuria. 5009970

1972
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD The RAGE axis in early diabetic retinopathy. 16043866

2005
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD To determine the role of glucagon action in diet-induced and genetic type 2 diabetes (T2D), we studied high-fat-diet-induced obese (DIO) and leptin receptor-defective (LepR(-/-)) rodents with and without glucagon receptors (GcgRs). 25157166

2014
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Adipocyte Xbp1s overexpression drives uridine production and reduces obesity. 29551634

2018
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker RGD Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Lepr(fa)/Lepr(fa) rat. 23154293

2011