Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD The combination of 31409163

2020

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0002103
Disease: Atopic rhinitis
Atopic rhinitis
0.200 Therapeutic RGD [Acupoint application of herbal paste relieves symptoms and naso-mucosal inflammatory response by down-regulating serum TGF-β1 in allergic rhinitis rats]. 31368266

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0027796
Disease: Neuralgia
Neuralgia
0.200 Therapeutic RGD Flexibilide obtained from cultured soft coral has anti-neuroinflammatory and analgesic effects through the upregulation of spinal transforming growth factor-β1 in neuropathic rats. 24979268

2014

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0156257
Disease: Calculus of kidney and ureter
Calculus of kidney and ureter
0.200 Therapeutic RGD Astaxanthin modulates osteopontin and transforming growth factor β1 expression levels in a rat model of nephrolithiasis: a comparison with citrate administration. 24712822

2014

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury
0.200 Therapeutic RGD Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats. 22913380

2013

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0041972
Disease: Urethral Obstruction
Urethral Obstruction
0.200 Therapeutic RGD [Effect of coicis semen oil on renal interstitial fibrosis in rats with unilateral urethral obstruction]. 24066596

2013

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia
0.200 Biomarker RGD Hyperlipidemia induced by high fat diet ingestion leads to renal injury in diabetic rats through activating TGF-beta1 /Smad signaling pathway. 19001732

2008

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0020476
Disease: Hyperlipoproteinemias
Hyperlipoproteinemias
0.200 Biomarker RGD [Hyperlipidemia induced by high fat diet ingestion activates TGF-beta/Smad signaling pathway in the kidney of diabetic rats]. 19001732

2008

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0206063
Disease: Radiation Pneumonitis
Radiation Pneumonitis
0.200 Biomarker RGD Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury. 18411002

2008

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0242706
Disease: Hyperoxia
Hyperoxia
0.200 Biomarker RGD [Influence of human bone marrow-derived mesenchymal stem cells on the lung of newborn rats damaged by hyperoxia]. 18353229

2008

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
Experimental Autoimmune Encephalomyelitis
0.200 Biomarker RGD Downregulation of transforming growth factor-beta2 facilitates inflammation in the central nervous system by reciprocal astrocyte/microglia interactions. 17204936

2007

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia
0.200 Therapeutic RGD The results indicate that JPQHR can improve the renal function of rats with chronic renal failure and hyperlipidemia by regulating lipid metabolism, maintaining balance between prooxidants and antioxidants and reducing expression of TGFbeta1 mRNA in renal tissue. 16834981

2006

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0020476
Disease: Hyperlipoproteinemias
Hyperlipoproteinemias
0.200 Therapeutic RGD [Effects of Jianpi Qinghua Recipe on oxygen radicals and transforming growth factor beta1 in renal tissue in a rat model of chronic renal failure with hyperlipidemia]. 16834981

2006

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker RGD Lesion-associated expression of transforming growth factor-beta-2 in the rat nervous system: evidence for down-regulating the phagocytic activity of microglia and macrophages. 14997937

2004

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Differential expression of cytokines in the rat heart in response to sustained volume overload. 15542404

2004

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0043020
Disease: Wallerian Degeneration
Wallerian Degeneration
0.200 Biomarker RGD Lesion-associated expression of transforming growth factor-beta-2 in the rat nervous system: evidence for down-regulating the phagocytic activity of microglia and macrophages. 14997937

2004

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0280725
Disease: Adult Cholangiocarcinoma
Adult Cholangiocarcinoma
0.200 Biomarker RGD In situ detection of TGF betas, TGF beta receptor II mRNA and telomerase activity in rat cholangiocarcinogenesis. 12632524

2003

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.210 Biomarker RGD Effects of Omega-3 Fatty Acids on Erectile Dysfunction in a Rat Model of Atherosclerosis-induced Chronic Pelvic Ischemia. 27051243

2016

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction
0.210 Biomarker RGD Role of increased penile expression of transforming growth factor-beta1 and activation of the Smad signaling pathway in erectile dysfunction in streptozotocin-induced diabetic rats. 18778311

2008

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0162770
Disease: Right Ventricular Hypertrophy
Right Ventricular Hypertrophy
0.210 Biomarker RGD Linear correlation analysis showed that HIF-1alpha mRNA, TGF-beta1 mRNA, TGF-beta1 protein were positively correlated with mPAP, vessel morphometry and right ventricular hypertrophy index. 17213961

2007

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.230 Biomarker RGD Messenger RNA levels of IL-6, ICAM-1, TNF-alpha, TGF-beta1, NF-kappaB in left ventricular tissues were lower than in the MS group, and volume of mitochondria and the phenotype of cardiac muscle cells in TEM were close to normal. 18692559

2008

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma
0.260 Biomarker RGD In situ detection of TGF betas, TGF beta receptor II mRNA and telomerase activity in rat cholangiocarcinogenesis. 12632524

2003

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1397307
Disease: Cardiac fibrosis
Cardiac fibrosis
0.300 Biomarker RGD Velvet antler peptide prevents pressure overload-induced cardiac fibrosis via transforming growth factor (TGF)-β1 pathway inhibition. 27108788

2016

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1969372
Disease: Tubulointerstitial fibrosis
Tubulointerstitial fibrosis
0.300 Biomarker RGD Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury. 23249995

2013

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker RGD These results demonstrate that cytokines and candidates playing a role in the pathogenesis of chronic diseases, such as TGF-beta1 and COX-1/-2, are over-expressed in platelets of Zucker obese rats by comparison to their lean counterparts. 16477387

2006