Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 GeneticVariation LHGDN Variations of human adrenomedullin gene and its relation to cardiovascular diseases. 12630823

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.300 GeneticVariation LHGDN However, there have been few studies examining the relationship between the AM gene and hypertension. 16097366

2005
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.060 GeneticVariation LHGDN In this study, we investigated the association between DNA variations in AM gene and the predisposition to develop nephropathy in type 2 diabetes mellitus. 12753312

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.040 GeneticVariation LHGDN Variations of human adrenomedullin gene and its relation to cardiovascular diseases. 12630823

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0033687
Disease: Proteinuria
Proteinuria 		0.010 GeneticVariation LHGDN Haplotype-based case-control study revealing an association between the adrenomedullin gene and proteinuria in subjects with essential hypertension. 16097366

2005
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0243026
Disease: Sepsis
Sepsis 		0.600 Biomarker LHGDN Adrenomedullin and endothelial barrier function. 18000597

2007
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker LHGDN Our data support that ADM may be associated with the pathophysiology of schizophrenia, although the cause of the association needs further study. 15194870

2004
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker LHGDN Collectively, these results support a protective role for increased AM in the cardiac hypertrophy and heart failure. 15974887

2005
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.270 Biomarker LHGDN With multiple regression analysis, plasma mature-adrenomedullin was found to be predicted by: stroke status (atherothrombotic ischemic stroke versus no cerebrovascular disease), diabetes status (yes/no), left ventricular ejection fraction, internal carotid artery intima-media thickness, and common carotid artery pressure strain elastic modulus (R = 0.79; F5,105 = 85.39, P < 0.0001). 15361766

2004
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0032914
Disease: Pre-Eclampsia
Pre-Eclampsia 		0.040 Biomarker LHGDN Adrenomedullin is decreased in preeclampsia because of failed response to epidermal growth factor and impaired syncytialization. 14517225

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0021368
Disease: Inflammation
Inflammation 		0.030 Biomarker LHGDN Plasma adrenomedullin concentration is increased in patients with peripheral arterial occlusive disease associated with vascular inflammation. 14759562

2004
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0021368
Disease: Inflammation
Inflammation 		0.030 Biomarker LHGDN Adrenomedullin and endothelial barrier function. 18000597

2007
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.030 Biomarker LHGDN Ovarian cancer cells express adrenomedullin mRNA for both the ligand and receptor and produce the peptide. 12969589

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0011875
Disease: Diabetic Angiopathies
Diabetic Angiopathies 		0.020 Biomarker LHGDN The relationship between adrenomedullin, metabolic factors, and vascular function in individuals with type 2 diabetes. 17384335

2007
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis 		0.020 Biomarker LHGDN The urine AM level was significantly lower in IgAN patients than in normal controls ( P < .01), whereas the plasma level was not different between the 2 groups. 15902095

2005
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.020 Biomarker LHGDN Overexpression of proadrenomedullin N-terminal 20 peptide blunts blood pressure rise and attenuates myocardial hypertrophy and fibrosis in hypertensive rats. 16115629

2005
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.020 Biomarker LHGDN Cardiac adrenomedullin: its role in cardiac hypertrophy and heart failure. 15974887

2005
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0036983
Disease: Septic Shock
Septic Shock 		0.020 Biomarker LHGDN Adrenomedullin and endothelial barrier function. 18000597

2007
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0206667
Disease: Adrenal Cortical Adenoma
Adrenal Cortical Adenoma 		0.020 Biomarker LHGDN Expression and function of adrenomedullin and its receptors in Conn's adenoma cells. 11712085

2001
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0003838
Disease: Arterial Occlusive Diseases
Arterial Occlusive Diseases 		0.010 Biomarker LHGDN Plasma adrenomedullin concentration is increased in patients with peripheral arterial occlusive disease associated with vascular inflammation. 14759562

2004
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0008495
Disease: Chorioamnionitis
Chorioamnionitis 		0.010 Biomarker LHGDN The present results thus suggested that mature AM may have some role in chorioamnionitis. 12565880

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension 		0.010 Biomarker LHGDN Furthermore, transplantation of AM DNA-transduced EPCs markedly ameliorated pulmonary hypertension in MCT rats (39% decrease in pulmonary vascular resistance). 12835224

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0020649
Disease: Hypotension
Hypotension 		0.010 Biomarker LHGDN In the EH group, the relationship between low blood pressure during HD and circulating levels of AM and ghrelin was also evaluated. 15758554

2005
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.010 Biomarker LHGDN Adrenomedullin is induced by hypoxia and enhances pancreatic cancer cell invasion. 17290391

2007
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0034186
Disease: Pyelonephritis
Pyelonephritis 		0.010 Biomarker LHGDN The plasma AM levels were lower in APN patients (33.40 +/- 2.27 pmol/mL) than in the control group (43.76 +/- 4.27 pmol/mL) (P < 0.001), whereas the urinary AM levels were higher in APN patients (248.58 +/- 140.63 pmol/mg urinary creatinine) than in the control group (49.42 +/- 45.23 pmol/mg) (P < 0.001). 16221100

2005