Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.020 AlteredExpression LHGDN (2) In COPD patients without pulmonary lobe resection, the plasma ADM level of group B was significantly higher than that of group A (P < 0.05), and the plasma ADM level had a significantly positive correlation with mPAP and pulmonary vascular resistance (PVR), but a negative correlation with PaO(2). 14720432

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.030 Biomarker LHGDN Ovarian cancer cells express adrenomedullin mRNA for both the ligand and receptor and produce the peptide. 12969589

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0022116
Disease: Ischemia
Ischemia 		0.010 PosttranslationalModification LHGDN Adrenomedullin gene delivery attenuates myocardial infarction and apoptosis after ischemia and reperfusion. 12805025

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0032914
Disease: Pre-Eclampsia
Pre-Eclampsia 		0.040 Biomarker LHGDN Adrenomedullin is decreased in preeclampsia because of failed response to epidermal growth factor and impaired syncytialization. 14517225

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.020 AlteredExpression LHGDN ADM-peptide expression in breast tumours was significantly correlated with axillary lymph node metastasis (P=0.030). 14612905

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.090 AlteredExpression LHGDN Adrenomedullin stimulated HCC cell growth via Akt activation, which was prevented by adrenomedullin peptide inhibitor. 18657357

2008
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0243026
Disease: Sepsis
Sepsis 		0.600 AlteredExpression LHGDN Adrenomedullin and adrenomedullin binding protein-1: their role in the septic response. 12643861

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0243026
Disease: Sepsis
Sepsis 		0.600 Biomarker LHGDN Adrenomedullin and endothelial barrier function. 18000597

2007
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0021368
Disease: Inflammation
Inflammation 		0.030 Biomarker LHGDN Adrenomedullin and endothelial barrier function. 18000597

2007
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0036983
Disease: Septic Shock
Septic Shock 		0.020 Biomarker LHGDN Adrenomedullin and endothelial barrier function. 18000597

2007
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0221002
Disease: Hyperparathyroidism, Primary
Hyperparathyroidism, Primary 		0.010 Biomarker LHGDN Adrenomedullin concentrations are elevated in plasma of patients with primary hyperparathyroidism. 12601625

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C3714514
Disease: Infection
Infection 		0.010 AlteredExpression LHGDN Adrenomedullin expression by gastric epithelial cells in response to infection. 12853384

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.210 PosttranslationalModification LHGDN Adrenomedullin gene delivery attenuates myocardial infarction and apoptosis after ischemia and reperfusion. 12805025

2003
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.030 AlteredExpression LHGDN Adrenomedullin inhibits prostate cancer cell proliferation through a cAMP-independent autocrine mechanism. 15336545

2004
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.010 Biomarker LHGDN Adrenomedullin is induced by hypoxia and enhances pancreatic cancer cell invasion. 17290391

2007
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.020 Biomarker LHGDN Cardiac adrenomedullin: its role in cardiac hypertrophy and heart failure. 15974887

2005
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 AlteredExpression LHGDN Cessation of pulmonary and coronary secretion of adrenomedullin peptides in the progression of human heart failure. 11972292

2002
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0243026
Disease: Sepsis
Sepsis 		0.600 AlteredExpression LHGDN Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis. 18080871

2008
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0036983
Disease: Septic Shock
Septic Shock 		0.020 AlteredExpression LHGDN Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis. 18080871

2008
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker LHGDN Collectively, these results support a protective role for increased AM in the cardiac hypertrophy and heart failure. 15974887

2005
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0242966
Disease: Systemic Inflammatory Response Syndrome
Systemic Inflammatory Response Syndrome 		0.010 AlteredExpression LHGDN Depending on the clinical severity of the infection, both CT-proET-1 and MR-proADM levels exhibited a gradual increase from Systemic Inflammatory Response Syndrome (SIRS) to sepsis and septic shock (p < .001). 18080871

2008
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0206667
Disease: Adrenal Cortical Adenoma
Adrenal Cortical Adenoma 		0.020 Biomarker LHGDN Expression and function of adrenomedullin and its receptors in Conn's adenoma cells. 11712085

2001
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C1261287
Disease: Stenosis
Stenosis 		0.010 Biomarker LHGDN Expression of adrenomedullin in hypoxic and ischemic rat kidneys and human kidneys with arterial stenosis. 14715486

2004
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0032914
Disease: Pre-Eclampsia
Pre-Eclampsia 		0.040 AlteredExpression LHGDN Fetal membranes, AdM may play an important role in the regulation of feto-placental hemodynamics and fetal physiology during pre-eclampsia. 16517613

2006
Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension 		0.010 Biomarker LHGDN Furthermore, transplantation of AM DNA-transduced EPCs markedly ameliorated pulmonary hypertension in MCT rats (39% decrease in pulmonary vascular resistance). 12835224

2003