Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.800 Biomarker RGD 4-Hydroxyacetophenone-induced choleresis in rats is mediated by the Mrp2-dependent biliary secretion of its glucuronide conjugate. 17009103

2006

Entrez Id: 1581
Gene Symbol: CYP7A1
CYP7A1
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.650 Therapeutic RGD Alisma orientale extract exerts the reversing cholestasis effect by activation of farnesoid X receptor. 29655695

2018

Entrez Id: 6554
Gene Symbol: SLC10A1
SLC10A1
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.220 Therapeutic RGD Alisma orientale extract exerts the reversing cholestasis effect by activation of farnesoid X receptor. 29655695

2018

Entrez Id: 1277
Gene Symbol: COL1A1
COL1A1
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.200 Biomarker RGD Aqueous extract of Artemisia iwayomogi Kitamura attenuates cholestatic liver fibrosis in a rat model of bile duct ligation. 22824087

2012

Entrez Id: 7082
Gene Symbol: TJP1
TJP1
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.200 Biomarker RGD Bile duct ligation in the rat causes upregulation of ZO-2 and decreased colocalization of claudins with ZO-1 and occludin. 18197414

2008

Entrez Id: 1277
Gene Symbol: COL1A1
COL1A1
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.200 Therapeutic RGD Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells. 21274875

2011

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.200 Therapeutic RGD Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells. 21274875

2011

Entrez Id: 1728
Gene Symbol: NQO1
NQO1
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.500 Therapeutic RGD Dioscin Protects ANIT-Induced Intrahepatic Cholestasis Through Regulating Transporters, Apoptosis and Oxidative Stress. 28337145

2017

Entrez Id: 345
Gene Symbol: APOC3
APOC3
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.200 Biomarker RGD Effect of bile duct obstruction on the expression of intestinal mRNA related to cholesterol and bile acid metabolism in the rat. 17201892

2007

Entrez Id: 64240
Gene Symbol: ABCG5
ABCG5
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.200 Biomarker RGD Effect of maternal cholestasis and treatment with ursodeoxycholic acid on the expression of genes involved in the secretion of biliary lipids by the neonatal rat liver. 16764892

2006

Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.200 Biomarker RGD Effect of maternal cholestasis and treatment with ursodeoxycholic acid on the expression of genes involved in the secretion of biliary lipids by the neonatal rat liver. 16764892

2006

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.200 Biomarker RGD Effect of vitamin A on the CD44 expression in the small intestine of rats with obstructive jaundice. 16804311

2006

Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.600 Therapeutic RGD Effects of corilagin on alleviating cholestasis via farnesoid X receptor-associated pathways in vitro and in vivo. 29235094

2018

Entrez Id: 8647
Gene Symbol: ABCB11
ABCB11
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.600 Biomarker RGD Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats. 12702498

2003

Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.800 Biomarker RGD Experimental LPS-induced cholestasis alters subcellular distribution and affects colocalization of Mrp2 and Bsep proteins: a quantitative colocalization study. 16037978

2005

Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.600 Therapeutic RGD Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures. 30223280

2018

Entrez Id: 10257
Gene Symbol: ABCC4
ABCC4
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.250 Therapeutic RGD Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures. 30223280

2018

Entrez Id: 10840
Gene Symbol: ALDH1L1
ALDH1L1
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.200 Therapeutic RGD Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures. 30223280

2018

Entrez Id: 2022
Gene Symbol: ENG
ENG
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.200 Biomarker RGD Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling. 21146604

2011

Entrez Id: 3240
Gene Symbol: HP
HP
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.200 Biomarker RGD Feeding of ursodeoxycholic and iso-ursodeoxycholic acid markedly down-regulated alpha2-macroglobulin and TIMP-1 expression in cholestasis but did not affect overexpression of beta-fibrinogen and haptoglobin. 12940443

2003

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.520 Biomarker RGD Gadolinium chloride, a Kupffer cell inhibitor, attenuates hepatic injury in a rat model of chronic cholestasis. 21339256

2011

Entrez Id: 5837
Gene Symbol: PYGM
PYGM
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.200 Biomarker RGD Hepatic and skeletal muscle glycogen metabolism in rats with short-term cholestasis. 11804660

2002

Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.520 Biomarker RGD Hepatic synthesis and urinary elimination of acetaminophen glucuronide are exacerbated in bile duct-ligated rats. 18096675

2008

Entrez Id: 3397
Gene Symbol: ID1
ID1
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.200 Biomarker RGD Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells. 16628634

2006

Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C0008370
Disease: Cholestasis
Cholestasis
0.520 Biomarker RGD In cholestasis, prolactin increased mrp3 manifestation of only in the distal renal tubules. 23486593

2013