Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0001308
Disease: Acute and subacute liver necrosis (disorder)
Acute and subacute liver necrosis (disorder) 		0.200 Biomarker RGD (Z)2-(5-(4-methoxybenzylidene)-2, 4-dioxothiazolidin-3-yl) acetic acid protects rats from CCl(4) -induced liver injury. 21913985

2012
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0267797
Disease: Acute hepatitis
Acute hepatitis 		0.200 Biomarker RGD (Z)2-(5-(4-methoxybenzylidene)-2, 4-dioxothiazolidin-3-yl) acetic acid protects rats from CCl(4) -induced liver injury. 21913985

2012
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury 		0.200 Biomarker RGD Cooperation of the inducible nitric oxide synthase and cytochrome P450 1A1 in mediating lung inflammation and mutagenicity induced by diesel exhaust particles. 16882535

2006
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0041228
Disease: African Trypanosomiasis
African Trypanosomiasis 		0.200 Biomarker RGD Cerebral and peripheral changes occurring in nitric oxide (NO) synthesis in a rat model of sleeping sickness: identification of brain iNOS expressing cells. 20169057

2010
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.300 Biomarker RGD The role of NOS in the impairment of spatial memory and damaged neurons in rats injected with amyloid beta 25-35 into the temporal cortex. 21163295

2011
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0042165
Disease: Anterior uveitis
Anterior uveitis 		0.200 Biomarker RGD Antibacterial and anti-inflammatory activity of traditional Chinese herb pairs, Angelica sinensis and Sophora flavescens. 21976127

2012
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C1332309
Disease: Anti-Basement Membrane Glomerulonephritis
Anti-Basement Membrane Glomerulonephritis 		0.200 Biomarker RGD Spleen tyrosine kinase promotes acute neutrophil-mediated glomerular injury via activation of JNK and p38 MAPK in rat nephrotoxic serum nephritis. 21894146

2011
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.200 Biomarker RGD Relationship between iNOS expression and aortic cell proliferation and apoptosis in an elastase-induced model of aorta aneurysm and the effect of 1400 W administration. 15800493

2005
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0003949
Disease: Asbestosis
Asbestosis 		0.500 Biomarker RGD Early inflammatory response to asbestos exposure in rat and hamster lungs: role of inducible nitric oxide synthase. 12051993

2002
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0004096
Disease: Asthma
Asthma 		0.600 Biomarker RGD Effects of inducible nitric oxide synthase inhibitors on asthma depending on administration schedule. 16540403

2006
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0004096
Disease: Asthma
Asthma 		0.600 Biomarker RGD Phosphatidylinositol 3-kinase inhibitor suppresses inducible nitric oxide synthase expression in bronchiole epithelial cells in asthmatic rats. 21847581

2012
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0023892
Disease: Biliary cirrhosis
Biliary cirrhosis 		0.510 Biomarker RGD Ammonia reduction with ornithine phenylacetate restores brain eNOS activity via the DDAH-ADMA pathway in bile duct-ligated cirrhotic rats. 21903766

2012
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0085129
Disease: Bronchial Hyperreactivity
Bronchial Hyperreactivity 		0.200 Biomarker RGD Lymphatic-borne IL-1beta and the inducible isoform of nitric oxide synthase trigger the bronchial hyporesponsiveness after intestinal ischema/reperfusion in rats. 17607157

2007
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0085129
Disease: Bronchial Hyperreactivity
Bronchial Hyperreactivity 		0.200 Biomarker RGD Elevated nitric oxide synthase activity concurrent with antigen-induced airway hyperresponsiveness in rats. 11076311

2001
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0085129
Disease: Bronchial Hyperreactivity
Bronchial Hyperreactivity 		0.200 Biomarker RGD Curcumin attenuates airway hyperreactivity induced by ischemia-reperfusion of the pancreas in rats. 20430162

2010
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0008677
Disease: Bronchitis, Chronic
Bronchitis, Chronic 		0.200 Biomarker RGD Effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf and MAPK signal transduction pathway on inducible nitric oxide synthase expression in alveolar macrophage of chronic bronchitis rats. 19938219

2009
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.560 Biomarker RGD Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns. 21171972

2010
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0149519
Disease: Chronic Persistent Hepatitis
Chronic Persistent Hepatitis 		0.200 Biomarker RGD (Z)2-(5-(4-methoxybenzylidene)-2, 4-dioxothiazolidin-3-yl) acetic acid protects rats from CCl(4) -induced liver injury. 21913985

2012
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0009319
Disease: Colitis
Colitis 		0.530 Biomarker RGD Expression of iNOS mRNA associated with suppression of colonic contraction in rat colitis. 16866779

2006
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker RGD The neuroprotective effect of agmatine after focal cerebral ischemia in diabetic rats. 21993016

2012
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.570 Biomarker RGD Inducible nitric oxide synthase mediates retinal DNA damage in Goto-Kakizaki rat retina. 18773271

2009
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0011875
Disease: Diabetic Angiopathies
Diabetic Angiopathies 		0.200 Biomarker RGD Expression of VEGF, iNOS, and eNOS is increased in cochlea of diabetic rat. 19241604

2008
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0011875
Disease: Diabetic Angiopathies
Diabetic Angiopathies 		0.200 Biomarker RGD Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats. 19587355

2009
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0013604
Disease: Edema
Edema 		0.200 Biomarker RGD Anti-inflammatory activities and mechanisms of action of the petroleum ether fraction of Rosa multiflora Thunb. hips. 22019508

2011
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.540 Biomarker RGD Beneficial effects of magnolol in a rodent model of endotoxin shock. 20519137

2010