Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0004096
Disease: Asthma
Asthma 		0.600 Biomarker RGD

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever 		0.700 Biomarker RGD Fever and formation of TNF-α and IL-6 induced by intraperitoneal injections of MALP-2 (1000 µg/kg) were completely blunted in TLR2-KO, while LPS (100 µg/kg)-induced responses were not abolished in these animals. 22042912

2012
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia 		0.600 Biomarker RGD IL-6 plasma bioactivity correlated significantly with spleen weight and weight loss, implicating IL-6 in the cachectic response. 9110147

1997
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction 		0.230 Therapeutic RGD Aim.  To evaluate the expression of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) after CN injury, and the effect of inhibiting IL-6 bioactivity on nerve injury-related ED. 21492407

2011
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.280 Biomarker RGD Akt pathway is required for oestrogen-mediated attenuation of lung injury in a rodent model of cerulein-induced acute pancreatitis. 20709317

2011
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0206504
Disease: Tympanic Membrane Perforation
Tympanic Membrane Perforation 		0.200 Biomarker RGD Analysis of gene expression profiles in tympanic membrane following perforation using PCR Array in rats--preliminary investigation. 24012216

2013
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0025295
Disease: Meningitis, Pneumococcal
Meningitis, Pneumococcal 		0.200 Biomarker RGD Analysis of nucleotide-binding oligomerization domain proteins in a murine model of pneumococcal meningitis. 25443778

2014
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015696
Disease: Fatty Liver, Alcoholic
Fatty Liver, Alcoholic 		0.210 Biomarker RGD Angiotensin-converting enzyme inhibitors improve hepatic steatosis by modulating expression of tumour necrosis factor-alpha, interleukin-6 and adiponectin receptor-2 in rats with type 2 diabetes. 19076162

2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0025295
Disease: Meningitis, Pneumococcal
Meningitis, Pneumococcal 		0.200 Therapeutic RGD Anti-interleukin-6 antibodies attenuate inflammation in a rat meningitis model. 11581077

2001
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.300 Biomarker RGD Application of thrombelastography in liver injury induced by endotoxin in rat. 22227956

2012
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0021368
Disease: Inflammation
Inflammation 		0.570 Therapeutic RGD Aqueous extract of Rosmarinus officinalis L. inhibits neutrophil influx and cytokine secretion. 25319517

2015
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0003969
Disease: Ascorbic Acid Deficiency
Ascorbic Acid Deficiency 		0.210 Biomarker RGD Ascorbic acid deficiency changes hepatic gene expression of acute phase proteins in scurvy-prone ODS rats. 9566989

1998
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction 		0.230 Therapeutic RGD Assessment of androgen replacement therapy for erectile function in rats with type 2 diabetes mellitus by examining nitric oxide-related and inflammatory factors. 24467772

2014
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0160390
Disease: Injury of liver
Injury of liver 		0.200 Therapeutic RGD Baicalein Reduces Liver Injury Induced by Myocardial Ischemia and Reperfusion. 27109160

2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker RGD Beneficial effects of physical training on the cardio-inflammatory disorder induced by lung ischemia/reperfusion in rats. 20680426

2011
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0020544
Disease: Renal hypertension
Renal hypertension 		0.200 Biomarker RGD Cardiorenal syndrome in hypertensive rats: microalbuminuria, inflammation and ventricular hypertrophy. 22188107

2012
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker RGD Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. 18976114

2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension 		0.200 Biomarker RGD Dexamethasone reverses monocrotaline-induced pulmonary arterial hypertension in rats. 20693255

2011
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Differential expression of cytokines in the rat heart in response to sustained volume overload. 15542404

2004
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.580 Biomarker RGD Dynamic response to peripheral nerve injury detected by in situ hybridization of IL-6 and its receptor mRNAs in the dorsal root ganglia is not strictly correlated with signs of neuropathic pain. 23953943

2013
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.580 Biomarker RGD Effect of tramadol on immune responses and nociceptive thresholds in a rat model of incisional pain. 18988309

2008
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0035328
Disease: Retinal Vein Occlusion
Retinal Vein Occlusion 		0.220 Biomarker RGD Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion. 21487926

2011
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0243026
Disease: Sepsis
Sepsis 		0.300 Biomarker RGD Effects of melatonin on cytokine release and healing of colonic anastomoses in an experimental sepsis model. 27598601

2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker RGD Effects of rosiglitazone and aspirin on experimental model of induced type 2 diabetes in rats: focus on insulin resistance and inflammatory markers. 19328014

2010
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0028754
Disease: Obesity
Obesity 		0.600 Biomarker RGD Excessive food intake, obesity and inflammation process in Zucker fa/fa rat pancreatic islets. 21826222

2011