Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Diabetes-induced, progressive endometrial involution characterization of periluminal epithelial lipoatrophy. 12502493

2003
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Conditioned taste aversion learning in leptin-receptor-deficient db/db mice. 12932425

2003
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD "Endocrine pancreatic cells of postnatal ""diabetes"" (db) mice in cell culture." 393618

1979
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice. 9299565

1997
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. 19015522

2008
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice. 15885672

2005
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Myocardial infarction and heart failure in the db/db diabetic mouse. 16113078

2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Adipocyte Xbp1s overexpression drives uridine production and reduces obesity. 29551634

2018
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD A new mutation (db3J) at the diabetes locus in strain 129/J mice. I. Physiological and histological characterization. 6993269

1980
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. 16971655

2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. 15207242

2004
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells. 24332968

2014
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Night-time restricted feeding normalises clock genes and Pai-1 gene expression in the db/db mouse liver. 15309293

2004
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Description of a new model of genetic obesity: the dbPas mouse. 3882910

1985
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Lepr(db/db) mice are obese due to a defect in the signaling portion of the leptin receptor, which has led to extensive study of this highly conserved system over the past several years. 15389315

2004
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. 12885755

2003
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker RGD Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats. 27465994

2016
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. 17268472

2007
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. 16443782

2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Severe pulmonary metastasis in obese and diabetic mice. 16998795

2006