Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression LHGDN Expression of angiogenic polypeptides vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) associate with clinical characteristics in human leukemia and lymphoma, and their serum concentrations serve as predictors of poor prognosis. 11999550

2002

Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0023418
Disease: leukemia
leukemia
0.050 AlteredExpression LHGDN Expression of angiogenic polypeptides vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) associate with clinical characteristics in human leukemia and lymphoma, and their serum concentrations serve as predictors of poor prognosis. 11999550

2002

Entrez Id: 7424
Gene Symbol: VEGFC
VEGFC
CUI: C0023418
Disease: leukemia
leukemia
0.010 AlteredExpression LHGDN VEGF and VEGF-C also act as survival factors on leukemia. 11999550

2002

Entrez Id: 2057
Gene Symbol: EPOR
EPOR
CUI: C0023418
Disease: leukemia
leukemia
0.050 Biomarker LHGDN Erythropoietin receptor in myelodysplastic syndrome and leukemia. 11999556

2002

Entrez Id: 863
Gene Symbol: CBFA2T3
CBFA2T3
CUI: C0023418
Disease: leukemia
leukemia
0.080 Biomarker LHGDN This case suggests the possibility that the region of the breakpoint of MTG16 is a characteristic of secondary leukemia. 11999578

2002

Entrez Id: 7799
Gene Symbol: PRDM2
PRDM2
CUI: C0023418
Disease: leukemia
leukemia
0.020 GeneticVariation LHGDN We analyzed nucleotide alteration of RIZ gene in human leukemia. 12002276

2002

Entrez Id: 3077
Gene Symbol: HFE
HFE
CUI: C0023418
Disease: leukemia
leukemia
0.040 GeneticVariation LHGDN Hemochromatosis gene in leukemia and lymphoma. 12002748

2002

Entrez Id: 4830
Gene Symbol: NME1
NME1
CUI: C0023418
Disease: leukemia
leukemia
0.060 AlteredExpression LHGDN These results show that the surface expression of NM23 proteins is related to cellular lineage and differentiation stage of leukemia line cells. 12007505

2002

Entrez Id: 4831
Gene Symbol: NME2
NME2
CUI: C0023418
Disease: leukemia
leukemia
0.010 AlteredExpression LHGDN To examine what types of tumor cell line express the cell surface NM23 protein, we measured the cell surface NM23-H1 and NM23-H2 proteins of leukemia line cells on various cellular lineage and differentiation stages. 12007505

2002

Entrez Id: 5879
Gene Symbol: RAC1
RAC1
CUI: C0023418
Disease: leukemia
leukemia
0.080 Biomarker LHGDN Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid. 12027902

2002

Entrez Id: 5880
Gene Symbol: RAC2
RAC2
CUI: C0023418
Disease: leukemia
leukemia
0.040 Biomarker LHGDN Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid. 12027902

2002

Entrez Id: 2678
Gene Symbol: GGT1
GGT1
CUI: C0023418
Disease: leukemia
leukemia
0.010 AlteredExpression LHGDN Gamma-glutamyl transpeptidase activity mediates NF-kappaB activation through lipid peroxidation in human leukemia U937 cells. 12030366

2002

Entrez Id: 5371
Gene Symbol: PML
PML
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression LHGDN Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions. 12032831

2002

Entrez Id: 3164
Gene Symbol: NR4A1
NR4A1
CUI: C0023418
Disease: leukemia
leukemia
0.030 AlteredExpression LHGDN Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions. 12032831

2002

Entrez Id: 2323
Gene Symbol: FLT3LG
FLT3LG
CUI: C0023418
Disease: leukemia
leukemia
0.050 AlteredExpression LHGDN Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors. 12036900

2002

Entrez Id: 79155
Gene Symbol: TNIP2
TNIP2
CUI: C0023418
Disease: leukemia
leukemia
0.010 AlteredExpression LHGDN The promyelocytic leukemia protein represses A20-mediated transcription. 12080044

2002

Entrez Id: 3727
Gene Symbol: JUND
JUND
CUI: C0023418
Disease: leukemia
leukemia
0.010 Biomarker LHGDN Ultraviolet-induced junD activation and apoptosis in myeloblastic leukemia ML-1 cells. 12082101

2002

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression LHGDN AML1 stimulates G1 to S progression via its transactivation domain. 12082641

2002

Entrez Id: 6886
Gene Symbol: TAL1
TAL1
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression LHGDN Ectopic expression of TAL-1 protein in Ly-6E.1-htal-1 transgenic mice induces defects in B- and T-lymphoid differentiation. 12091340

2002

Entrez Id: 699
Gene Symbol: BUB1
BUB1
CUI: C0023418
Disease: leukemia
leukemia
0.040 GeneticVariation LHGDN hBUB1 defects in leukemia and lymphoma cells. 12096343

2002

Entrez Id: 4671
Gene Symbol: NAIP
NAIP
CUI: C0023418
Disease: leukemia
leukemia
0.010 AlteredExpression LHGDN This view is supported by the fact that NAIP-deltaEx10-11 mRNA and protein were much less expressed in the multidrug- and apoptosis-resistant HL60R leukemia than in its parental counterpart HL60.The opposite occurred for regular NAIP. 12127562

2002

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker LHGDN Anticancer-drug-induced apoptotic cell death in leukemia cells is associated with proteolysis of beta-catenin. 12127563

2002

Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker LHGDN [The significance of cyclin E expression and cyclin E-dependent kinase inhibitor in adult acute leukemia]. 12133429

2002

Entrez Id: 898
Gene Symbol: CCNE1
CCNE1
CUI: C0023418
Disease: leukemia
leukemia
0.020 Biomarker LHGDN [The significance of cyclin E expression and cyclin E-dependent kinase inhibitor in adult acute leukemia]. 12133429

2002

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0023418
Disease: leukemia
leukemia
0.010 AlteredExpression LHGDN [The correlation of cyclin A gene expression with drug resistance in adult acute leukemia patients]. 12133445

2002