Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.300 Therapeutic RGD IL-10 mediated by herpes simplex virus vector reduces neuropathic pain induced by HIV gp120 combined with ddC in rats. 25078297

2014
Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.300 Biomarker RGD We recently documented that intrathecal IL-10 protein resolves neuropathic pain, albeit briefly (approximately 2-3 h), given its short half-life. 16949747

2006
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.300 Biomarker RGD Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain. 15145554

2004
Entrez Id: 64805
Gene Symbol: P2RY12
P2RY12
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.240 Biomarker RGD Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn. 20665560

2010
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.220 Biomarker RGD The role of the dopamine D2 receptor in descending control of pain induced by motor cortex stimulation in the neuropathic rat. 22902996

2012
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.220 Biomarker RGD We determined the changes in dopamine D1 and D2 (D1R and D2R) receptor expression in the ACC (cg1 and cg2) in an animal model of neuropathic pain. 22171983

2011
Entrez Id: 156
Gene Symbol: GRK2
GRK2
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.210 Therapeutic RGD These results suggest that the glial-neuronal GRK2 pathway is a potentially important new target for treating neuropathic pain. 24216329

2014
Entrez Id: 3684
Gene Symbol: ITGAM
ITGAM
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.210 Biomarker RGD Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain. 15145554

2004
Entrez Id: 1072
Gene Symbol: CFL1
CFL1
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.200 Therapeutic RGD Simvastatin Attenuates Neuropathic Pain by Inhibiting the RhoA/LIMK/Cofilin Pathway. 27216618

2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.200 Therapeutic RGD Flexibilide obtained from cultured soft coral has anti-neuroinflammatory and analgesic effects through the upregulation of spinal transforming growth factor-β1 in neuropathic rats. 24979268

2014
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.200 Therapeutic RGD Electroacupuncture can alleviate neuropathic pain in CCI rats, which is closely related to its effect in down-regulating the expression of nNOS protein and mRNA in the spinal cord. 23342771

2012
Entrez Id: 1812
Gene Symbol: DRD1
DRD1
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.200 Biomarker RGD Expression of the dopaminergic D1 and D2 receptors in the anterior cingulate cortex in a model of neuropathic pain. 22171983

2011
Entrez Id: 3791
Gene Symbol: KDR
KDR
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.200 Biomarker RGD The present study investigated the effects of VEGF and VEGF receptor-2 (VEGFR2) on the pain transmission in neuropathic pain states that mediated by P2X₂(/)₃ receptor in primary sensory neurons. 20705122

2010
Entrez Id: 1522
Gene Symbol: CTSZ
CTSZ
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.200 Biomarker RGD Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model. 18700000

2008
Entrez Id: 1520
Gene Symbol: CTSS
CTSS
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.200 Biomarker RGD Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model. 18700000

2008
Entrez Id: 1520
Gene Symbol: CTSS
CTSS
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.200 Biomarker RGD Here, we report that in peripheral nerve-injured rats, the lysosomal cysteine protease cathepsin S (CatS) is critical for the maintenance of neuropathic pain and spinal microglia activation. 17551020

2007
Entrez Id: 152
Gene Symbol: ADRA2C
ADRA2C
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.200 Biomarker RGD Decreased spinal alpha2a- and alpha2c-adrenergic receptor subtype mRNA in a rat model of neuropathic pain. 12946573

2003
Entrez Id: 150
Gene Symbol: ADRA2A
ADRA2A
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.200 Biomarker RGD Decreased spinal alpha2a- and alpha2c-adrenergic receptor subtype mRNA in a rat model of neuropathic pain. 12946573

2003