| Gene | Gene Full Name | DSI g | DPI g | pLI | Disease | Type | Score gda | EL gda | EI gda | N. PMIDs | N. SNPs gda | First Ref. | Last Ref. | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
amyloid beta precursor protein | 0.422 | 0.846 | 4.7E-02 |
|
disease | 0.600 | None | 0.980 | 199 | 11 | 1993 | 2020 | ||||||||
|
HtrA serine peptidase 1 | 0.532 | 0.692 | 4.9E-04 |
|
disease | 0.410 | strong | 1.000 | 1 | 0 | 2014 | 2015 | ||||||||
|
notch receptor 3 | 0.435 | 0.808 | 0.41 |
|
disease | 0.400 | strong | 1.000 | 11 | 1 | 2007 | 2019 | ||||||||
|
clusterin | 0.426 | 0.885 | 7.8E-05 |
|
disease | 0.380 | None | 1.000 | 8 | 1 | 2011 | 2019 | ||||||||
|
phosphatidylinositol binding clathrin assembly protein | 0.592 | 0.538 | 1.00 |
|
disease | 0.360 | None | 1.000 | 6 | 0 | 2011 | 2018 | ||||||||
|
calcium voltage-gated channel subunit alpha1 C | 0.510 | 0.846 | 1.00 |
|
disease | 0.340 | None | 1.000 | 4 | 2 | 2014 | 2018 | ||||||||
|
sortilin related receptor 1 | 0.582 | 0.692 | 7.7E-11 |
|
disease | 0.330 | None | 1.000 | 3 | 1 | 2013 | 2018 | ||||||||
|
bridging integrator 1 | 0.550 | 0.692 | 0.78 |
|
disease | 0.320 | None | 1.000 | 2 | 0 | 2014 | 2018 | ||||||||
|
fatty acid 2-hydroxylase | 0.573 | 0.654 | 0.15 |
|
disease | 0.310 | strong | 1.000 | 1 | 0 | 2013 | 2019 | ||||||||
|
beta-secretase 1 | 0.559 | 0.769 | 0.88 |
|
disease | 0.300 | None | 0.963 | 26 | 0 | 2006 | 2020 | ||||||||
|
interleukin 1 beta | 0.276 | 0.962 | 0.13 |
|
disease | 0.300 | None | 1.000 | 22 | 0 | 2007 | 2019 | ||||||||
|
ADAM metallopeptidase domain 10 | 0.489 | 0.846 | 1.00 |
|
disease | 0.240 | None | 1.000 | 4 | 0 | 2009 | 2019 | ||||||||
|
protein phosphatase 1 regulatory subunit 9B | 0.678 | 0.423 | 1.00 |
|
disease | 0.210 | None | 1.000 | 1 | 0 | 2013 | 2017 | ||||||||
|
brain derived neurotrophic factor | 0.345 | 0.923 | 0.66 |
|
disease | 0.200 | None | 0.989 | 181 | 5 | 2006 | 2020 | ||||||||
|
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | 0.292 | 0.923 | 1.00 |
|
disease | 0.200 | None | 1.000 | 23 | 0 | 2012 | 2019 | ||||||||
|
dystrophin | 0.423 | 0.923 | 1.00 |
|
disease | 0.200 | None | 0.857 | 14 | 0 | 1994 | 2019 | ||||||||
|
mechanistic target of rapamycin kinase | 0.343 | 0.885 | 1.00 |
|
disease | 0.200 | None | 0.917 | 12 | 1 | 2013 | 2020 | ||||||||
|
sodium voltage-gated channel alpha subunit 1 | 0.477 | 0.808 | 1.00 |
|
disease | 0.200 | None | 1.000 | 10 | 0 | 2001 | 2019 | ||||||||
|
AKT serine/threonine kinase 1 | 0.311 | 0.962 | 0.98 |
|
disease | 0.190 | None | 1.000 | 9 | 0 | 2011 | 2020 | ||||||||
|
glutamate ionotropic receptor NMDA type subunit 2B | 0.510 | 0.692 | 1.00 |
|
disease | 0.190 | None | 1.000 | 9 | 0 | 2015 | 2020 | ||||||||
|
insulin receptor | 0.432 | 0.846 | 3.6E-05 |
|
disease | 0.180 | None | 1.000 | 8 | 0 | 2005 | 2020 | ||||||||
|
spastin | 0.579 | 0.577 | 1.00 |
|
disease | 0.170 | None | 1.000 | 7 | 0 | 2000 | 2018 | ||||||||
|
glial cell derived neurotrophic factor | 0.434 | 0.885 | 0.20 |
|
disease | 0.150 | None | 1.000 | 5 | 0 | 2017 | 2019 | ||||||||
|
solute carrier family 2 member 1 | 0.388 | 0.808 | 0.99 |
|
disease | 0.150 | None | 1.000 | 5 | 0 | 2014 | 2019 | ||||||||
|
SPG11 vesicle trafficking associated, spatacsin | 0.576 | 0.538 | 1.6E-39 |
|
disease | 0.150 | None | 1.000 | 5 | 0 | 1999 | 2019 |