Source: ORPHANET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C2931038
Disease: Pancreatic carcinoma, familial
Pancreatic carcinoma, familial 		0.400 SusceptibilityMutation ORPHANET To study these relationships in more detail, we examined whether BRCA2 germline mutations are associated with familial pancreatic cancer. 12569143

2003
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C2931038
Disease: Pancreatic carcinoma, familial
Pancreatic carcinoma, familial 		0.390 SusceptibilityMutation ORPHANET Germline mutations in PALB2 have been identified in approximately 1-2% of familial breast cancer and 3-4% of familial pancreatic cancer cases. 21365267

2011
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C2931038
Disease: Pancreatic carcinoma, familial
Pancreatic carcinoma, familial 		0.390 SusceptibilityMutation ORPHANET PALB2 mutations in European familial pancreatic cancer families. 20412113

2010
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C2931038
Disease: Pancreatic carcinoma, familial
Pancreatic carcinoma, familial 		0.380 SusceptibilityMutation ORPHANET Familial and sporadic pancreatic cancer share the same molecular pathogenesis. 25240578

2015
Entrez Id: 23022
Gene Symbol: PALLD
PALLD
CUI: C2931038
Disease: Pancreatic carcinoma, familial
Pancreatic carcinoma, familial 		0.330 SusceptibilityMutation ORPHANET These observations suggest that the presence of an abnormal palladin gene in familial pancreatic cancer and the overexpression of palladin protein in sporadic pancreatic cancer cause cytoskeletal changes in pancreatic cancer and may be responsible for or contribute to the tumor's strong invasive and migratory abilities. 17194196

2006
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C2931038
Disease: Pancreatic carcinoma, familial
Pancreatic carcinoma, familial 		0.320 SusceptibilityMutation ORPHANET Prevalence and characteristics of pancreatic cancer in families with BRCA1 and BRCA2 mutations. 18855126

2009
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
CUI: C2931038
Disease: Pancreatic carcinoma, familial
Pancreatic carcinoma, familial 		0.310 SusceptibilityMutation ORPHANET Familial and sporadic pancreatic cancer share the same molecular pathogenesis. 25240578

2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C2931038
Disease: Pancreatic carcinoma, familial
Pancreatic carcinoma, familial 		0.310 SusceptibilityMutation ORPHANET Familial and sporadic pancreatic cancer share the same molecular pathogenesis. 25240578

2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2931038
Disease: Pancreatic carcinoma, familial
Pancreatic carcinoma, familial 		0.300 SusceptibilityMutation ORPHANET Familial and sporadic pancreatic cancer share the same molecular pathogenesis. 25240578

2015