Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1584
Gene Symbol: CYP11B1
CYP11B1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker RGD Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension. 19837774

2010
Entrez Id: 1584
Gene Symbol: CYP11B1
CYP11B1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.400 Biomarker RGD Central infusion of aldosterone synthase inhibitor prevents sympathetic hyperactivity and hypertension by central Na+ in Wistar rats. 18495825

2008
Entrez Id: 1584
Gene Symbol: CYP11B1
CYP11B1
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.220 Biomarker RGD [Effects of various diuretics on cardiac function in rats with heart failure]. 19571523

2009
Entrez Id: 1584
Gene Symbol: CYP11B1
CYP11B1
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.200 Biomarker RGD Fetal adrenal gland alterations in a rat model of adverse intrauterine environment. 19923365

2010
Entrez Id: 1584
Gene Symbol: CYP11B1
CYP11B1
CUI: C0018801
Disease: Heart failure
Heart failure 		0.200 Biomarker RGD [Effects of various diuretics on cardiac function in rats with heart failure]. 19571523

2009
Entrez Id: 1584
Gene Symbol: CYP11B1
CYP11B1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.200 Biomarker RGD Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction. 18689429

2009
Entrez Id: 1584
Gene Symbol: CYP11B1
CYP11B1
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker RGD Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats. 18582458

2008
Entrez Id: 1584
Gene Symbol: CYP11B1
CYP11B1
CUI: C0027059
Disease: Myocarditis
Myocarditis 		0.200 Biomarker RGD Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy. 18154949

2008
Entrez Id: 1584
Gene Symbol: CYP11B1
CYP11B1
CUI: C0001126
Disease: Renal tubular acidosis
Renal tubular acidosis 		0.200 Biomarker RGD Metabolic acidosis has dual effects on sodium handling by rat kidney. 16495212

2006
Entrez Id: 1584
Gene Symbol: CYP11B1
CYP11B1
CUI: C0016059
Disease: Fibrosis
Fibrosis 		0.200 Biomarker RGD Mineralocorticoid receptor antagonist spironolactone prevents pig serum-induced hepatic fibrosis in rats. 16938653

2006
Entrez Id: 1584
Gene Symbol: CYP11B1
CYP11B1
CUI: C0001925
Disease: Albuminuria
Albuminuria 		0.200 Biomarker RGD Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage. 15939810

2005
Entrez Id: 1584
Gene Symbol: CYP11B1
CYP11B1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage. 15939810

2005
Entrez Id: 1584
Gene Symbol: CYP11B1
CYP11B1
CUI: C0018799
Disease: Heart Diseases
Heart Diseases 		0.200 Biomarker RGD Cardiac specific increase in aldosterone production induces coronary dysfunction in aldosterone synthase-transgenic mice. 15364804

2004