Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension 		0.500 Biomarker CTD_human These data suggest that 5-LO plays a critical role in the progression of pulmonary hypertension in rats and that the detrimental effect of 5-LO is manifest only in the setting of pulmonary vascular endothelial cell dysfunction. 14726295

2004
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker CTD_human Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton. 15266012

2004
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0004096
Disease: Asthma
Asthma 		0.500 Biomarker CTD_human

Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.400 Biomarker CTD_human In contrast to human plaques, levels of 5-LO mRNA are not significantly increased in plaque tissues from two atherosclerosis-prone mouse strains, and mouse plaques exhibit segregated cellular expression of LTA4H and 5-LO as well as strong increases of CysLT1 and CysLT2 mRNA. 16698924

2006
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.370 Biomarker CTD_human Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. 30258081

2018
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.370 Biomarker CTD_human A heterotopic xenograft model in athymic mice using HT29 and LoVo human colon cancer cells was used to evaluate the effect of the 5-LOX inhibitor zileuton on tumor growth. 18927292

2008
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.370 Biomarker CTD_human Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway. 14569062

2004
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.360 Biomarker CTD_human Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. 30258081

2018
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.350 Biomarker CTD_human Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. 30258081

2018
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.350 Biomarker CTD_human Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth. 20061081

2010
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.350 Therapeutic CTD_human Treatment of CML mice with a 5-LO inhibitor also impaired the function of LSCs similarly by affecting LT-LSCs, and prolonged survival. 19503090

2009
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.350 Therapeutic CTD_human We believe that our discovery of the role of Alox5 in regulating the function of LSCs in CML reminds us of viewing CSCs at a different angel. 19823023

2009
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.350 Biomarker CTD_human From transcriptome to proteome: differentially expressed proteins identified in synovial tissue of patients suffering from rheumatoid arthritis and osteoarthritis by an initial screen with a panel of 791 antibodies. 12833524

2003
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.330 Biomarker CTD_human Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. 30258081

2018
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.330 Biomarker CTD_human Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model. 18927292

2008
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.330 Biomarker CTD_human Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway. 14569062

2004
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.320 Biomarker CTD_human Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. 30258081

2018
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.320 Biomarker CTD_human Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. 30258081

2018
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.320 Biomarker CTD_human Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. 30258081

2018
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0001430
Disease: Adenoma
Adenoma 		0.320 Biomarker CTD_human Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model. 18927292

2008
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0042109
Disease: Urticaria
Urticaria 		0.320 Biomarker CTD_human Genetic markers for differentiating aspirin-hypersensitivity. 16502481

2006
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.310 Biomarker CTD_human Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. 30258081

2018
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.310 Biomarker CTD_human Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. 30258081

2018
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.310 Biomarker CTD_human Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. 30258081

2018
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.310 Biomarker CTD_human Nicotine activated 5-lipoxygenase (5-LOX) in three gastric cancer cell lines (MKN-45, MKN-28 and AGS). 20061081

2010