×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
Nephroblastoma
0.800
GeneticVariation
LHGDN
These findings imply a possible role for GPC3 in Wilms' tumour development.
12085187 2002
×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
Liver carcinoma
0.600
AlteredExpression
LHGDN
Collectively, these results suggest that progression of hepatocellular carcinoma is associated with upregulation of GPC3 .
16682817 2006
×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
Liver carcinoma
0.600
AlteredExpression
LHGDN
GPC3 immunostaining was positive in all HCC s and negative in dysplastic nodules (22/22 vs 0/14, respectively, P < .001).17087938 2006
×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
Liver carcinoma
0.600
Biomarker
LHGDN
Our study raises the possibility that these GPC3 peptides may therefore be applicable to cancer immunotherapy for a large number of HCC patients.
16675560 2006
×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
Liver carcinoma
0.600
Biomarker
LHGDN
We report here that a mutant GPC3 that cannot be processed by convertases is still able to play its stimulatory role in Wnt activity and HCC growth.
16227623 2005
×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
Liver carcinoma
0.600
AlteredExpression
LHGDN
By Western blot analysis carried out with a monoclonal anti-GPC3 antibody we generated, the GPC3 protein was found to be overexpressed in 6 hepatoma cell lines, HepG2, Hep3B, HT17, HuH6, HuH7 and PLC/PRF/5, as well as 22 tumors (42.3%).
12478660 2003
×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
Liver carcinoma
0.600
AlteredExpression
LHGDN
We conclude that GPC3 is a good molecular marker for HCC .
12824919 2003
×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
Hepatoblastoma
0.400
Biomarker
LHGDN
All 65 hepatoblastomas had cytoplasmic immunoreactivity for GPC3 with greater than 90% of cases showing strong, diffuse positivity.
17949790 2008
×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
Yolk Sac Tumor
0.060
Biomarker
LHGDN
All but one YST (97%), including those associated with mixed germ cell tumor were positive for GPC3 , whereas all teratomas and embryonal carcinomas were negative.
18277882 2008
×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
melanoma
0.040
Biomarker
LHGDN
We recently identified glypican-3 (GPC3 ) as a novel tumor marker but could diagnose only 40% of melanomas .
16299239 2005
×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
melanoma
0.040
Biomarker
LHGDN
Twenty-seven of 36 serum GPC3 -positive patients were negative for both serum 5-S-cysteinyldopa and melanoma-inhibitory activity, well-known tumor markers for melanoma .
15475451 2004
×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
Squamous cell carcinoma
0.020
AlteredExpression
LHGDN
Among smokers, glypican-3 mRNA expression was reduced in adenocarcinoma patients (P=0.013), and was elevated in those with squamous cell carcinoma (P=0.03, interaction P=0.0009).
18469798 2008
×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
Merkel cell carcinoma
0.010
AlteredExpression
LHGDN
All MCC cases were either positive for both GPC3 and CK20 (37 cases) or at least 1 of the markers (18 cases, 16 CK20 only and 2 GPC3 only).
18813128 2009
×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
Carcinoma, Neuroendocrine
0.010
AlteredExpression
LHGDN
Frequent expression of glypican-3 in Merkel cell carcinoma: an immunohistochemical study of 55 cases.
18813128 2009
×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
Carcinoma, Papillary
0.010
AlteredExpression
LHGDN
In 69 cases of papillary carcinoma , GPC3 was expressed at an early stage, suggesting that GPC3 expression in thyroid cancer is an early event in developing papillary carcinoma .
18511877 2007
×
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
Thyroid Neoplasm
0.010
AlteredExpression
LHGDN
Further studies are required to determine biological functions and molecular mechanisms underlying the upregulation of GPC3 in thyroid cancer .
18511877 2007