Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation LHGDN A novel point mutation in the amino terminal domain of the human glucocorticoid receptor (hGR) gene enhancing hGR-mediated gene expression. 18827003

2008
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.600 AlteredExpression LHGDN Reduced Glucocorticoid Receptor alpha Expression in Mood Disorder Patients and First-Degree Relatives. 16458268

2006
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 AlteredExpression LHGDN Compared with control subjects, GR mRNA expression was reduced in the basolateral/lateral nuclei in schizophrenia and bipolar disorder. 15576061

2004
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 AlteredExpression LHGDN Compared with control subjects, GR mRNA expression was reduced in the basolateral/lateral nuclei in schizophrenia and bipolar disorder. 15576061

2004
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0028840
Disease: Ocular Hypertension
Ocular Hypertension 		0.340 GeneticVariation LHGDN The variant N363S of glucocorticoid receptor in steroid-induced ocular hypertension in Hungarian patients treated with photorefractive keratectomy. 17563720

2007
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.300 GeneticVariation LHGDN Glucocorticoid receptor variants may predispose to rheumatoid arthritis susceptibility. 18830906

2009
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.300 Biomarker LHGDN Glucocorticoid receptor beta in acute and chronic inflammatory conditions: clinical implications. 16446173

2006
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0004096
Disease: Asthma
Asthma 		0.300 AlteredExpression LHGDN Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma. 16387802

2006
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0004096
Disease: Asthma
Asthma 		0.300 Biomarker LHGDN [Response to glucocorticoid treatment in asthma. The role of alpha and beta isoforms of the glucocorticoid receptor]. 12237016

2002
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.300 GeneticVariation LHGDN A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis. 11708406

2001
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0015672
Disease: Fatigue
Fatigue 		0.130 GeneticVariation LHGDN Glucocorticoid receptor polymorphisms and haplotypes associated with chronic fatigue syndrome. 16740143

2007
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia 		0.120 Biomarker LHGDN Stimulation of both type I and type II corticosteroid receptors blunts counterregulatory responses to subsequent hypoglycemia in healthy man. 18182467

2008
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0221406
Disease: Pituitary-dependent Cushing's disease
Pituitary-dependent Cushing's disease 		0.100 Biomarker LHGDN Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease. 17043312

2006
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 GeneticVariation LHGDN The identified mutation of the GR gene may represent a polymorphism associated with SLE. 15212141

2004
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.090 AlteredExpression LHGDN We identified reduced GR expression in human SCLC cell lines, compared to a non-SCLC cell line. 17496926

2007
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.070 Biomarker LHGDN Changes of glucocorticoid receptor expression in the nasal polyps of patients with chronic sinusitis following treatment with glucocorticoid. 18396779

2008
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.070 GeneticVariation LHGDN The data suggest a role for glucocorticoid receptor variation in the underlying cause of CAD. 12623935

2003
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.060 GeneticVariation LHGDN We genotyped 118 children diagnosed with NS who initially responded to oral GC treatment [steroid-responsive nephrotic syndrome (SRNS) group] and 136 healthy children for three intron B single nucleotide polymorphisms of NR3C1, namely Bcl I (C/G), rs33389 (C/T) and rs33388 (A/T). 18343955

2008
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.060 AlteredExpression LHGDN Glucocorticoid receptor changes its cellular location with breast cancer development. 17952860

2008
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.060 GeneticVariation LHGDN Genetic variations of the NR3C1 gene in children with sporadic nephrotic syndrome. 16890204

2006
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.060 AlteredExpression LHGDN Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. 15590693

2005
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.060 GeneticVariation LHGDN [Analysis on association of glucocorticoid receptor gene polymorphism with steroid-resistance in idiopathic nephrotic syndrome of children]. 14733805

2003
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0023418
Disease: leukemia
leukemia 		0.050 Biomarker LHGDN Human glucocorticoid receptor alpha transcript splice variants with exon 2 deletions: evidence for tissue- and cell type-specific functions. 15895983

2005
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.040 Biomarker LHGDN It is concluded that the genetic information about GRL would be useful for further genetic study of obesity, diabetes, and related metabolic diseases. 18983327

2008
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0339143
Disease: Thyroid associated opthalmopathies
Thyroid associated opthalmopathies 		0.030 GeneticVariation LHGDN The significant association between the frequency of the polymorphic BclI allele and ATA stage distribution suggests that this polymorphism of the GR gene may affect clinical manifestations of GO, presumably due to an increased signaling of endogenous glucocorticoids. 18156379

2008