Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.700 Biomarker RGD A putative role for hypothalamic glucocorticoid receptors in hypertension induced by prenatal undernutrition in the rat. 20674672

2010

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD [Effects of ginsenosides on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor in rats exposed to chronic unpredictable mild stress]. 21837980

2011

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.310 Biomarker RGD These findings provide a mechanistic link between stress-induced motor disability and GR activation in a rat model of stroke. 20858282

2010

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker RGD Functional variability in corticosteroid receptors is a major component of strain differences in fat deposition and metabolic consequences of enriched diets in rat. 20723946

2011

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0038436
Disease: Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder
0.300 Biomarker RGD The expression of GR gradually increased on days 1, 4, and 7, but decreased on days 14 and 28, respectively.MR and GR in the locus coeruleus may have a role in the development of long-term persistent neuropsychological sequelae in PTSD. 21584742

2011

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0004096
Disease: Asthma
Asthma
0.300 Therapeutic RGD Medicinal extract for tonifying kidney to relieve asthma can increase the expression of GR in lung tissues of asthmatic rats, which may be one of its mechanisms in preventing and treating asthma. 20727335

2010

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.300 Biomarker RGD Modeling corticosteroid effects in a rat model of rheumatoid arthritis I: mechanistic disease progression model for the time course of collagen-induced arthritis in Lewis rats. 18448865

2008

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
Diabetes Mellitus, Non-Insulin-Dependent
0.280 Biomarker RGD The approach of inhibiting the hepatic GR may be an advantageous treatment paradigm for individuals with type 2 diabetes mellitus. 17292727

2007

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
0.250 Biomarker RGD Stress-induced activation of ovarian heat shock protein 90 in a rat model of polycystic ovary syndrome. 22176470

2012

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0018801
Disease: Heart failure
Heart failure
0.250 Therapeutic RGD Glucocorticoids improve renal responsiveness to atrial natriuretic peptide by up-regulating natriuretic peptide receptor-A expression in the renal inner medullary collecting duct in decompensated heart failure. 21737535

2011

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.250 Therapeutic RGD Glucocorticoids improve renal responsiveness to atrial natriuretic peptide by up-regulating natriuretic peptide receptor-A expression in the renal inner medullary collecting duct in decompensated heart failure. 21737535

2011

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0243026
Disease: Sepsis
Sepsis
0.250 Therapeutic RGD [The effect of low-dose hydrocortisone on the expression of glucocorticoid receptor alpha of the septic kidney and its protective effect on kidney in rat]. 21787473

2011

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation
0.240 Biomarker RGD Intrauterine growth retardation affects expression and epigenetic characteristics of the rat hippocampal glucocorticoid receptor gene. 20388836

2010

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.240 Biomarker RGD Alpha glucocorticoid receptor expression in different experimental rat models of acute lung injury. 17467318

2008

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation
0.240 Biomarker RGD Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension. 17272666

2007

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0042164
Disease: Uveitis
Uveitis
0.210 Biomarker RGD The aldosterone-mineralocorticoid receptor pathway exerts anti-inflammatory effects in endotoxin-induced uveitis. 23152847

2012

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0042164
Disease: Uveitis
Uveitis
0.210 Biomarker RGD Differential regulations of AQP4 and Kir4.1 by triamcinolone acetonide and dexamethasone in the healthy and inflamed retina. 21724913

2011

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Left ventricular gene expressions of aldosterone synthase, mineralocorticoid receptor, and hydroxysteroid dehydrogenase type 2 were the same in the 3 groups, whereas gene expression of the glucocorticoid receptor was significantly diminished in chronic renal failure rats. 18591458

2008

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Biomarker RGD Left ventricular gene expressions of aldosterone synthase, mineralocorticoid receptor, and hydroxysteroid dehydrogenase type 2 were the same in the 3 groups, whereas gene expression of the glucocorticoid receptor was significantly diminished in chronic renal failure rats. 18591458

2008

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0376618
Disease: Endotoxemia
Endotoxemia
0.210 Biomarker RGD Inhibition of glucocorticoid receptor binding by nitric oxide in endotoxemic rats. 15640646

2004

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.200 Biomarker RGD Expression of glucocorticoid receptor and glucose transporter-1 during placental development in the diabetic rat. 21744335

2011

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0024636
Disease: Malocclusion
Malocclusion
0.200 Biomarker RGD Occlusal disharmony increases amyloid-β in the rat hippocampus. 21751079

2011

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.200 Biomarker RGD Nr3c1 (glucocorticoid receptor) mRNA levels on the other hand were down-regulated at 24h, 10 days and 2 months, post SE. 22050960

2011

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0270824
Disease: Visual seizure
Visual seizure
0.200 Biomarker RGD [Effects of neonatal recurrent seizures on glucocorticoid receptor expression in the rat brain]. 20113635

2010

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0013604
Disease: Edema
Edema
0.200 Biomarker RGD Fluoroquinolones reduce carrageenan-induced edema in rats and the involvement of the glucocorticoid receptor system. 19396522

2009