Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0040015
Disease: Thrombasthenia
Thrombasthenia 		1.000 Biomarker MGD

Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C1861195
Disease: Glanzmann Thrombasthenia, Autosomal Dominant
Glanzmann Thrombasthenia, Autosomal Dominant 		0.900 Biomarker MGD Beta3 integrin deficiency promotes cardiac hypertrophy and inflammation. 17184791

2007
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C1861195
Disease: Glanzmann Thrombasthenia, Autosomal Dominant
Glanzmann Thrombasthenia, Autosomal Dominant 		0.900 Biomarker MGD Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. 11786903

2002
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C1861195
Disease: Glanzmann Thrombasthenia, Autosomal Dominant
Glanzmann Thrombasthenia, Autosomal Dominant 		0.900 Biomarker MGD Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. 9916135

1999
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.590 Biomarker RGD Analysis of combined treatment of embolic stroke in rat with r-tPA and a GPIIb/IIIa inhibitor. 15678115

2005
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C4304021
Disease: Autosomal dominant macrothrombocytopenia
Autosomal dominant macrothrombocytopenia 		0.510 Biomarker MGD Beta3 integrin deficiency promotes cardiac hypertrophy and inflammation. 17184791

2007
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C4304021
Disease: Autosomal dominant macrothrombocytopenia
Autosomal dominant macrothrombocytopenia 		0.510 Biomarker MGD Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. 11786903

2002
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C4304021
Disease: Autosomal dominant macrothrombocytopenia
Autosomal dominant macrothrombocytopenia 		0.510 Biomarker MGD Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. 9916135

1999
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.200 Biomarker RGD Quantification of epithelial cell differentiation in mammary glands and carcinomas from DMBA- and MNU-exposed rats. 22022542

2011
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.200 Biomarker RGD Differential regulation of osteopontin receptors, CD44 and the alpha(v) and beta(3) integrin subunits, in the rat hippocampus following transient forebrain ischemia. 18638458

2008
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0477317
Disease: Other primary thrombocytopenia
Other primary thrombocytopenia 		0.200 Biomarker MGD Beta3 integrin deficiency promotes cardiac hypertrophy and inflammation. 17184791

2007
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.200 Biomarker RGD Glycoprotein IIB/IIIA-inhibition and microcirculatory alterations during experimental endotoxemia--an intravital microscopic study in the rat. 15280099

2005
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0004626
Disease: Pneumonia, Bacterial
Pneumonia, Bacterial 		0.200 Biomarker RGD Expression of integrin subunits alphav and beta3 in acute lung inflammation. 15114484

2004
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker RGD Latent transforming growth factor-beta binding protein-1, a component of latent transforming growth factor-beta complex, accelerates the migration of aortic smooth muscle cells in diabetic rats through integrin-beta3. 12606526

2003
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0477317
Disease: Other primary thrombocytopenia
Other primary thrombocytopenia 		0.200 Biomarker MGD Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. 11786903

2002
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker RGD Platelets modulate ischemia/reperfusion-induced leukocyte recruitment in the mesenteric circulation. 11705748

2001
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0477317
Disease: Other primary thrombocytopenia
Other primary thrombocytopenia 		0.200 Biomarker MGD Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. 9916135

1999
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0003838
Disease: Arterial Occlusive Diseases
Arterial Occlusive Diseases 		0.200 Biomarker RGD Inhibition of the intimal hyperplasia in an arterial autograft model by blockade of the N-terminal of the integrin beta3 subunit by monoclonal antibody P37. 16793666

1997
Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.200 Biomarker RGD Fibrinogen mediates platelet-polymorphonuclear leukocyte cooperation during immune-complex glomerulonephritis in rats. 8083378

1994