Source: MGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0018553
Disease: Hamartoma Syndrome, Multiple
Hamartoma Syndrome, Multiple 		1.000 Biomarker MGD Germ-line mutations of PTEN cause Cowden's syndrome (CS), a multiple hamartoma condition resulting in increased susceptibility for the development of cancer. 10910075

2000
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0018553
Disease: Hamartoma Syndrome, Multiple
Hamartoma Syndrome, Multiple 		1.000 Biomarker MGD Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. 9990064

1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0018553
Disease: Hamartoma Syndrome, Multiple
Hamartoma Syndrome, Multiple 		1.000 Biomarker MGD These results support the notion that PTEN haploinsufficiency plays a causal role in CD, LDD and BZS pathogenesis, and demonstrate that Pten is a tumour suppressor essential for embryonic development. 9697695

1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0018553
Disease: Hamartoma Syndrome, Multiple
Hamartoma Syndrome, Multiple 		1.000 Biomarker MGD PTEN is widely expressed, and Cowden disease consistently affects various organ systems, suggesting that the PTEN protein must have an important, although as yet poorly understood, function in cellular physiology. 9799734

1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		1.000 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0391826
Disease: Lhermitte-Duclos disease
Lhermitte-Duclos disease 		1.000 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C1854416
Disease: MACROCEPHALY/AUTISM SYNDROME
MACROCEPHALY/AUTISM SYNDROME 		0.910 Biomarker MGD Germline disruption of Pten localization causes enhanced sex-dependent social motivation and increased glial production. 24470394

2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium 		0.600 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.600 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.600 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.600 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.520 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0206682
Disease: Follicular thyroid carcinoma
Follicular thyroid carcinoma 		0.400 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		0.400 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.300 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.300 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.300 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.300 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.270 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006111
Disease: Brain Diseases
Brain Diseases 		0.220 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0015696
Disease: Fatty Liver, Alcoholic
Fatty Liver, Alcoholic 		0.200 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0021847
Disease: Intestinal Pseudo-Obstruction
Intestinal Pseudo-Obstruction 		0.200 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0031190
Disease: Persistent Fetal Circulation Syndrome
Persistent Fetal Circulation Syndrome 		0.200 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0085584
Disease: Encephalopathies
Encephalopathies 		0.200 Biomarker MGD

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma 		0.200 Biomarker MGD