Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862939
Disease: AMYOTROPHIC LATERAL SCLEROSIS 1
AMYOTROPHIC LATERAL SCLEROSIS 1 		1.000 Biomarker MGD A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity. 25468678

2015
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0085084
Disease: Motor Neuron Disease
Motor Neuron Disease 		0.700 Biomarker MGD A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity. 25468678

2015
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.600 Biomarker MGD A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity. 25468678

2015
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.560 Biomarker RGD Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats. 16716903

2006
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism 		0.500 Therapeutic RGD Curcumin differentially regulates the expression of superoxide dismutase in cerebral cortex and cerebellum of L-thyroxine (T₄)-induced hyperthyroid rat brain. 22476324

2013
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker RGD The chronological characteristics of SOD1 activity and inflammatory response in the hippocampi of STZ-induced type 1 diabetic rats. 20924670

2011
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C3542025
Disease: AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE
AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE 		0.300 Biomarker MGD A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity. 25468678

2015
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.300 Biomarker RGD Changes in copper metabolism in different compartments of the brain in rats with induced fibrillogenesis. 20027333

2009
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0020676
Disease: Hypothyroidism
Hypothyroidism 		0.210 Therapeutic RGD Declined translated products of SOD1 and SOD2 in cerebellum of PTU-treated rats were alleviated on administration of curcumin to hypothyroid rats. 22076484

2012
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0020676
Disease: Hypothyroidism
Hypothyroidism 		0.210 Biomarker RGD Decreased SOD1 and SOD2 activities in hypothyroid rats compared to control were either unaltered or further decreased in response to the antioxidants. 21607622

2012
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0013238
Disease: Dry Eye Syndromes
Dry Eye Syndromes 		0.210 Biomarker MGD

Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0019284
Disease: Diaphragmatic Hernia
Diaphragmatic Hernia 		0.200 Biomarker RGD Possible role of increased oxidative stress in pulmonary hypertension in experimental diaphragmatic hernia. 26534761

2016
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0010692
Disease: Cystitis
Cystitis 		0.200 Biomarker RGD Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. 26109091

2015
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C1096249
Disease: Calcification of the aorta
Calcification of the aorta 		0.200 Biomarker RGD Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification. 25430697

2015
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0243026
Disease: Sepsis
Sepsis 		0.200 Biomarker RGD Regulation of lung oxidative damage by endogenous superoxide dismutase in sepsis. 26266917

2014
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.200 Therapeutic RGD Sulfur dioxide preconditioning increases antioxidative capacity in rat with myocardial ischemia reperfusion (I/R) injury. 23629152

2013
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0022680
Disease: Polycystic Kidney Diseases
Polycystic Kidney Diseases 		0.200 Biomarker RGD Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease. 23006058

2012
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery 		0.200 Biomarker RGD Inhibition of sonic hedgehog signaling aggravates brain damage associated with the down-regulation of Gli1, Ptch1 and SOD1 expression in acute ischemic stroke. 22133807

2012
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery 		0.200 Therapeutic RGD Polydatin modulates inflammation by decreasing NF-κB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain. 22001340

2012
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0152136
Disease: Low Tension Glaucoma
Low Tension Glaucoma 		0.200 Biomarker MGD The levels of SOD-1 and -2 were measured by ELISA, in the serum of 47 newly diagnosed consecutive normal tension glaucoma (NTG) patients and 44 consecutive control subjects. 21421868

2011
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0242184
Disease: Hypoxia
Hypoxia 		0.200 Therapeutic RGD Analysis of expression levels of SOD revealed that NAP significantly activated antioxidant genes as compared to hypoxia exposed rats. 21453737

2011
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0028840
Disease: Ocular Hypertension
Ocular Hypertension 		0.200 Biomarker RGD Proteomic analysis of rat retina in a steroid-induced ocular hypertension model: potential vulnerability to oxidative stress. 18626730

2008
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0035066
Disease: Renal Artery Obstruction
Renal Artery Obstruction 		0.200 Biomarker RGD Chronic hypoxia aggravates renal injury via suppression of Cu/Zn-SOD: a proteomic analysis. 17959751

2008
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0024667
Disease: Animal Mammary Neoplasms
Animal Mammary Neoplasms 		0.200 Biomarker RGD Prenatal TCDD exposure predisposes for mammary cancer in rats. 17157473

2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy 		0.200 Therapeutic RGD Superoxide dismutase isoforms 1 and 2 in lumbar spinal cord of neonatal rats after sciatic nerve transection and melatonin treatment. 15707675

2005