Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0600467
Disease: Neurogenic Inflammation
Neurogenic Inflammation 		0.500 Biomarker RGD These findings suggest that SP acts via the NK-1 receptor to provoke neurogenic inflammation, oxidative stress, and ICAM-1 expression after OSE in rats. 18326823

2008
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0030193
Disease: Pain
Pain 		0.280 Biomarker RGD NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin. 18407414

2008
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0004096
Disease: Asthma
Asthma 		0.230 Biomarker RGD In summary, bronchial epithelial cell changes in asthma are induced by LIF which promotes the expression of NK-1R, and JAK/STAT pathway and MAPK/ERK pathway may participate in this process. 17392578

2006
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0004096
Disease: Asthma
Asthma 		0.230 Biomarker RGD LIF and NK-1R were excessively expressed and closely correlated in lungs of the rat asthmatic model, suggesting that LIF may be involved in modulating airway neurogenic inflammation. 16409782

2005
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0009319
Disease: Colitis
Colitis 		0.220 Biomarker RGD Spatial and temporal expression of tachykinins and NK1- and NK2-receptor gene during TNB induced colitis in rats. 18715640

2009
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0010692
Disease: Cystitis
Cystitis 		0.210 Biomarker RGD Cyclophosphamide induced cystitis: role of nitric oxide synthase, cyclooxygenase-1 and 2, and NK(1) receptors. 17382773

2007
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0020649
Disease: Hypotension
Hypotension 		0.200 Biomarker RGD Exercise reduces GABA synaptic input onto nucleus tractus solitarii baroreceptor second-order neurons via NK1 receptor internalization in spontaneously hypertensive rats. 19261870

2009
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0020649
Disease: Hypotension
Hypotension 		0.200 Biomarker RGD TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats. 18337316

2008
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0030305
Disease: Pancreatitis
Pancreatitis 		0.200 Biomarker RGD Role of substance P and bradykinin in acute pancreatitis induced by secretory phospholipase A2. 18580444

2008
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0085129
Disease: Bronchial Hyperreactivity
Bronchial Hyperreactivity 		0.200 Biomarker RGD Estrogen determines sex differences in airway responsiveness after allergen exposure. 18063836

2008
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0520680
Disease: Sleep Apnea, Central
Sleep Apnea, Central 		0.200 Biomarker RGD Gradual loss of preBötC NK1R neurons may be an underlying factor of sleep-disordered breathing, in particular of central sleep apnea. 18420958

2008
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0021368
Disease: Inflammation
Inflammation 		0.200 Biomarker RGD Substance P is involved in the cutaneous blood flow increase response to sympathetic nerve stimulation in persistently inflamed rats. 18053315

2007
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.200 Biomarker RGD Neurokinin-1 receptor antagonism in a rat model of subarachnoid hemorrhage: prevention of upregulation of contractile ETB and 5-HT1B receptors and cerebral blood flow reduction. 17542534

2007
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension 		0.200 Biomarker RGD Tachykinin dysfunction attenuates monocrotaline-induced pulmonary hypertension. 12662901

2003
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0267941
Disease: Pancreatitis, Acute Necrotizing
Pancreatitis, Acute Necrotizing 		0.200 Biomarker RGD Western blot analysis showed overexpression of NK-1R protein level exited in ANP group. 12857498

2003
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0002103
Disease: Atopic rhinitis
Atopic rhinitis 		0.200 Biomarker RGD [Expression of substance P receptor mRNA in nasal mucosa of rat in allergic rhinitis model]. 12768696

2000
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0035235
Disease: Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus Infections 		0.200 Therapeutic RGD Respiratory syncytial virus upregulates expression of the substance P receptor in rat lungs. 10516226

1999